ArticleTranslational cancer research2026
Liquid-liquid phase separation-related gene signature characterizes prognostic subtypes and therapeutic sensitivities in gastric cancer.
Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Gastric cancer (GC) is a heterogeneous malignancy with variable outcomes. Liquid-liquid phase separation (LLPS) has emerged as a regulator of cancer-related processes. The study aims to identify GC subgroups associated with LLPS and to establish a prognostic model for patient outcomes. Methods: The Cancer Genome Atlas (TCGA) GC transcriptomic and clinical data were analyzed. LLPS-related genes were obtained from the Phase Separation Database. Differential expression analysis and unsupervised consensus clustering were performed to define molecular subtypes. A prognostic RiskScore was constructed using least absolute shrinkage and selection operator (LASSO) Cox regression and validated in independent Gene Expression Omnibus cohorts (GSE84437, GSE66229, GSE28541). Intrinsically disordered regions (IDRs) were predicted using the Intrinsically Unstructured Protein Predictor. Model performance and clinical utility were assessed using time-dependent receiver operating characteristic (ROC) curve analysis and decision curve analysis (DCA). Immune cell infiltration, immunotherapy responsiveness, functional pathway enrichment, and drug sensitivity were analyzed using established computational frameworks. Results: A three-gene LLPS-related prognostic signature ( Conclusions: An LLPS-related three-gene RiskScore identifies GC subgroups with different prognosis, immune features, and therapeutic sensitivity.
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