Evidence map›Paper›PMID 42305529›Full record

ReviewFrontiers in immunology2026

HPV-specific innovations and controversies in therapeutic strategies for HPV-associated oropharyngeal carcinoma.

Yulun He, Jiaqi Tang, Yun Li, Yating Hu, Yaodong He, Xiaolong Zhang, Yanbing Yao, Jiale Wang, Kunyu Chen, Yuqi Wang and 2 more

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Yulun HeState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases, and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, Air Force Medical University, Xi'an, China.
Jiaqi TangState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases, and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, Air Force Medical University, Xi'an, China.
Yun LiState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases, and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, Air Force Medical University, Xi'an, China.
Yating HuState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases, and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, Air Force Medical University, Xi'an, China.
Yaodong HeState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases, and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, Air Force Medical University, Xi'an, China.
Xiaolong ZhangState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases, and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, Air Force Medical University, Xi'an, China.
Yanbing YaoState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases, and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, Air Force Medical University, Xi'an, China.
Jiale WangState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases, and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, Air Force Medical University, Xi'an, China.
Kunyu ChenState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases, and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, Air Force Medical University, Xi'an, China.
Yuqi WangState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases, and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, Air Force Medical University, Xi'an, China.
Huan LiState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases, and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, Air Force Medical University, Xi'an, China.
Jianhua WeiState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases, and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, Air Force Medical University, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global surge in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) has necessitated a fundamental shift in clinical management. While patients exhibit favorable prognoses compared to HPV-negative counterparts, balancing oncological cure rates with toxicity reduction remains a critical challenge. This review elucidates the virological mechanisms driven by oncoproteins E6 and E7 and evaluates novel diagnostic biomarkers, emphasizing the utility of liquid biopsy (circulating tumor HPV DNA,ctHPV DNA) and artificial intelligence for dynamic risk stratification. We critically examine current therapeutic controversies, particularly the risks of recurrence associated with unguided treatment de-escalation. Furthermore, the article highlights innovations in precision medicine, including immune reactivation strategies leveraging viral antigens (therapeutic vaccines, adoptive cell therapy) and targeted interventions exploiting metabolic vulnerabilities (PI3K/Akt/mTOR pathway) and DNA damage repair defects. Ultimately, we advocate transitioning from static TNM staging to a multidimensional, adaptive treatment model integrating genomics and immunology to achieve precise, individualized care for HPV-associated OPSCC.

Indexed as

Human Papillomavirus VirusesOropharyngeal NeoplasmsPapillomaviridaePapillomavirus InfectionsBiomarkers, TumorHumansPrecision MedicineBiomarkers, TumorEVLPlung transplantationlung transplant - ischemia-reperfusion injuryprimary graft dysfunctionprimary graft dysfunction risk modification

Identifiers

PMID42305529
PMCPMC13265459

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.