Evidence map›Paper›PMID 42306049›Full record

ArticleBioactive materials2026

The miR-212-3p/transferrin axis promotes bone regeneration by modulating iron homeostasis through Schwann cell Exosome-BMSCs communication.

Yukun Jia, Ningdao Li, Dagang Tang, Wendan Pu, Zhiqiang Feng, Yingtao Duan, Yafei Zhu, Juan Wang, Xiaoji Luo, Jun Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yukun JiaDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine, Orthopaedic Research Laboratory of Chongqing Medical University, China.
Ningdao LiDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine, Orthopaedic Research Laboratory of Chongqing Medical University, China.
Dagang TangDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine, Orthopaedic Research Laboratory of Chongqing Medical University, China.
Wendan PuDepartment of Pharmaceutics, College of Pharmacy, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Zhiqiang FengDepartment of Pharmaceutics, College of Pharmacy, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Yingtao DuanDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine, Orthopaedic Research Laboratory of Chongqing Medical University, China.
Yafei ZhuDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine, Orthopaedic Research Laboratory of Chongqing Medical University, China.
Juan WangDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaoji LuoDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine, Orthopaedic Research Laboratory of Chongqing Medical University, China.
Jun ZhangDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine, Orthopaedic Research Laboratory of Chongqing Medical University, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional bone regeneration relies on cross talk between nerves and bone, yet the regulatory mechanisms linking Schwann cells (SCs) to osteoporotic bone marrow mesenchymal stem cells (OP-BMSCs) remain unclear. This study demonstrated that SC-Exosomes (Exos) promoted the osteogenic differentiation of OP-BMSCs, and miRNA-mRNA sequencing revealed that SC-Exos, which contained the key mediator miR-212-3p, facilitated osteogenesis by suppressing the ferroptosis pathway in OP-BMSCs. miR-212-3p overexpression combined with transferrin (TF) knockdown or overexpression confirmed that miR-212-3p suppresses TF expression and validated the role of the miR-212-3p/TF axis, which maintained iron homeostasis in BMSCs, alleviated iron overload and oxidative stress, and promoted osteogenic differentiation. Furthermore, an injectable SC-Exos-loaded gelatin methacrylate hydrogel (SC-Exos/GelMA) targeting BMSCs was constructed.

Indexed as

Bone marrow mesenchymal stem cellsBone regenerationFerroptosisOsteoporosisSchwann cell-derived exosomes

Identifiers

PMID42306049
PMCPMC13265684

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.