ArticleNeuropsychiatric disease and treatment2026
Therapeutic Potential of Naive Hair Follicle Stem Cells in Alzheimer's Disease: A Comprehensive Evaluation of Neuroprotection and Neurogenesis.
Article in Neuropsychiatric disease and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: As a highly prevalent neurological condition, Alzheimer's disease (AD) imposes considerable economic pressure on global societies. Its core pathological feature is progressive degeneration within the central nervous system (CNS), a feature which establishes it as the leading trigger for dementia worldwide. Currently available therapies for AD are largely palliative and lack restorative efficacy. While stem cell transplantation holds promise for brain regeneration, the shortage of transplantable neural stem cells and ethical constraints remains a significant limitation. Hair follicle stem cells (HFSCs) are easily accessible, proliferative, low immunogenicity, and free of ethical concerns, making them an ideal candidate for neurodegenerative disease therapy. However, the application of naive, unmodified HFSCs in AD therapy has not been thoroughly explored. In contrast to our previous study using NGF-modified HFSCs, the present study used unmodified naive HFSCs to systematically evaluate their therapeutic effects in AD rats, focusing on neurogenesis, synaptic protection, and microglial polarization. Therefore, the present assessment sought a more complete understanding of HFSCs' intrinsic therapeutic potential. Methods: We induced AD in rats via intrahippocampal injection of Aβ Results: HFSCs transplantation not only markedly upregulated the synaptic proteins SYP and PSD-95, but also promoted neurogenesis and alleviated microglial overactivation in the AD rat hippocampus. Conclusion: HFSCs represent a highly promising therapeutic strategy for AD. When delivered via transplantation, these cells protect against synaptic and neuronal injury, boost hippocampal neurogenesis, and prevent abnormal overactivation of microglia in the cerebral tissues of AD model rats. Together, these results offer comprehensive preclinical proof of the intrinsic therapeutic potential of unmodified HFSCs, distinguishing it from previous studies using genetically modified cells and laying a solid foundation for future clinical translation.
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