ArticleReumatologia2026
Clinical and laboratory differences in characteristics of patients with early-onset and late-onset systemic lupus erythematosus: a single-center retrospective study.
Article in Reumatologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Introduction: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with clinical and laboratory characteristics influenced by the age of onset. Despite its significance, data on late-onset SLE (Lo-SLE) compared to early-onset SLE (Eo-SLE) remain limited, particularly in the Polish population. We investigated differences between Lo-SLE and Eo-SLE patients (using 50 years as a cutoff), aiming to improve the diagnosis and management of SLE patients across different age groups. Material and methods: We conducted a retrospective analysis of medical records from all SLE patients treated at the University Hospital in Krakow, Poland, from 2012 to 2022. All included patients met the 2019 European Alliance of Associations for Rheumatology and American College of Rheumatology classification criteria for SLE. Results: We analyzed 710 patients with Eo-SLE (77.9%) and 201 patients with Lo-SLE (22.1%). Compared to the Eo-SLE group, the Lo-SLE group exhibited shorter disease duration ( Conclusions: Late-onset SLE patients exhibit different disease manifestations but with a higher prevalence of interstitial lung disease, internal medicine comorbidities, malignancies, and cardiovascular events compared to Eo-SLE. Our findings highlight the need for tailored management strategies in elderly SLE patients.
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