In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
20 authors.
Hao JiaDepartment of Cardiac Surgery, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China.ORCID 0000-0002-4736-0957 Xiao ChenState Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China.ORCID 0009-0002-6916-3548 Yuan ChangDepartment of Cardiac Surgery, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China.ORCID 0000-0002-0966-7966 Yifan WangDepartment of Cardiac Surgery, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China.ORCID 0000-0002-4762-529X Hao CuiBeijing Key Laboratory for Xenotransplantation, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID 0000-0003-2319-8980 Yihang FengState Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China.ORCID 0009-0006-4532-8685 Ningning ZhangState Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China.ORCID 0009-0009-5124-1772 Xiulin ZhangBeijing Key Laboratory for Xenotransplantation, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID 0000-0003-2964-4769 Mengda XuDepartment of Cardiac Surgery, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China.ORCID 0000-0002-6785-118X Dan ShanState Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China.ORCID 0000-0001-8680-6416 Yixuan ShengState Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China.ORCID 0009-0008-6778-4643 Fengxiang WeiThe Genetics Laboratory, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City, Longgang Maternity and Child Institute of Shantou University Medical College, Shenzhen, China.ORCID 0000-0001-7559-2504 Xiumeng HuaDepartment of Cardiac Surgery, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China.ORCID 0009-0006-5424-8812 Han MoShenzhen Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen, China.ORCID 0000-0002-5089-9638 Yuhong HuDepartment of Cardiac Surgery, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China.ORCID 0009-0002-2771-6968 Xijia ShaoDepartment of Cardiac Surgery, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China.ORCID 0009-0002-2318-2743 Han HanDepartment of Cardiac Surgery, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China.ORCID 0009-0001-8714-401X Jiangping SongDepartment of Cardiac Surgery, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China.ORCID 0000-0002-9488-7823 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
The human heart undergoes continuous transcriptional remodeling from development through aging, yet the cellular and regulatory features governing this process remain incompletely defined. Here, we generated a single-nucleus RNA sequencing atlas of 442,239 nuclei from 54 nonfailing myocardial tissues of 29 individuals spanning development, adulthood, and aging, covering left and right ventricles. Across all major cell types, we uncovered coordinated yet cell type-specific transcriptional trajectories that converge on progressive loss of gene expression homeostasis, stress responses, and inflammatory signaling over the life span. Cardiomyocytes displayed distinct age-associated transcriptional states enriched for senescence- and disease-related signatures. Regulatory network analysis identified
Indexed as
AgingHeartLongevityMyocardiumTranscription, GeneticAdultAgedAnimalsCellular SenescenceFemaleGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksHumansMaleMiceTranscription Factors
Identifiers
PMID42308288
PMCPMC13274588
What Socratic holds
Textmetadata
LicenceCC BY
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