Evidence map›Paper›PMID 42308306›Full record

ArticleScience advances2026

Untethered thin-film neurostimulator wrapped around tiny nerve trunks for wireless neuromodulation.

Renyuan Sun, Wenyuan Wang, Wenliang Liu, Ming Yang, Dingke Zhang, Zhonghao Zou, Kun Yang, Chuan Gao, Jiahui She, Ziyu Zhang and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Renyuan SunNational Engineering Research Center for Nanomedicine, Research Center for Intelligent Fiber Devices and Equipment, State Key Laboratory of New Textile Materials and Advanced Processing, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0000-0002-9607-878X
Wenyuan WangDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.ORCID 0000-0002-2653-7207
Wenliang LiuNational Engineering Research Center for Nanomedicine, Research Center for Intelligent Fiber Devices and Equipment, State Key Laboratory of New Textile Materials and Advanced Processing, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0009-0000-4304-1142
Ming YangMaterials Research Laboratory, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0009-0004-5416-7591
Dingke ZhangNational Engineering Research Center for Nanomedicine, Research Center for Intelligent Fiber Devices and Equipment, State Key Laboratory of New Textile Materials and Advanced Processing, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Zhonghao ZouNational Engineering Research Center for Nanomedicine, Research Center for Intelligent Fiber Devices and Equipment, State Key Laboratory of New Textile Materials and Advanced Processing, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Kun YangNational Engineering Research Center for Nanomedicine, Research Center for Intelligent Fiber Devices and Equipment, State Key Laboratory of New Textile Materials and Advanced Processing, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Chuan GaoNational Engineering Research Center for Nanomedicine, Research Center for Intelligent Fiber Devices and Equipment, State Key Laboratory of New Textile Materials and Advanced Processing, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Jiahui SheNational Engineering Research Center for Nanomedicine, Research Center for Intelligent Fiber Devices and Equipment, State Key Laboratory of New Textile Materials and Advanced Processing, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Ziyu ZhangNational Engineering Research Center for Nanomedicine, Research Center for Intelligent Fiber Devices and Equipment, State Key Laboratory of New Textile Materials and Advanced Processing, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Zhi HuNational Engineering Research Center for Nanomedicine, Research Center for Intelligent Fiber Devices and Equipment, State Key Laboratory of New Textile Materials and Advanced Processing, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Feng HuBrain-Computer Interface Research Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Wei JiangBrain-Computer Interface Research Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0000-0001-8155-2269
Kai ShuBrain-Computer Interface Research Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Mingxing XieDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Zhouping TangBrain-Computer Interface Research Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0000-0002-4153-8590
Li ZhangDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.ORCID 0000-0003-1620-1512
Cunjiang YuMaterials Research Laboratory, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0002-0155-0368
Zhiqiang LuoNational Engineering Research Center for Nanomedicine, Research Center for Intelligent Fiber Devices and Equipment, State Key Laboratory of New Textile Materials and Advanced Processing, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0000-0003-3867-6607

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrical stimulation of tiny peripheral nerve trunks for near-organ neuromodulation enables precise electroceutical therapy for refractory diseases, but long-term stable neuromodulation of these delicate, fragile nerve trunks remains an engineering challenge. Here, we report the development of NeuroWrap Ultrasonic Stimulator (NWUS), an untethered, self-adhesive thin-film neurostimulator capable of conformally wrapping around tiny nerve trunks. The untethered architecture can help avoid the damage or rupture of tiny nerves due to uncontrollable micromotion of lead wires during bodily movements. The NWUS is an ultrasound-responsive acoustoelectric converter with optimized impedance matching, which enables highly effective wireless electrical stimulation. The electroceutical application of NWUS was further illustrated in chronic vagus nerve stimulation for immunomodulation therapy in a rat model. The wireless neuromodulation therapy of rat experimental autoimmune myocarditis was proven to restore left ventricular function, suppress proinflammatory cytokine expression as well as macrophage infiltration within cardiac tissue, and promote regulatory T cell recruitment along with increased anti-inflammatory cytokine levels.

Indexed as

Implantable NeurostimulatorsVagus Nerve StimulationWireless TechnologyAnimalsCytokinesDisease Models, AnimalRatsVagus NerveCytokines

Identifiers

PMID42308306
PMCPMC13274598

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.