ArticleVirulence2026
mmu_circ_0012122/mmu-miR-1843-5p/Sertad2 axis: A novel regulatory pathway in rabies virus infection.
Article in Virulence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rabies virus (RABV) causes severe central nervous system damage, though the underlying mechanisms remain unclear. Circular RNAs (circRNAs) have been identified in various cells and tissues and are known to regulate gene expression in eukaryotes. Here, we investigated the expression patterns of circRNAs in brain tissues from mice infected with two strains of RABV (CVS-11 and SRV9) and compared them to brain tissues from uninfected mice. Differential expression analysis identified 1,306 circRNAs, primarily derived from coding exons, with functional enrichment implicating synaptic and nervous system pathways. Critically, we identified and validated a novel regulatory axis, mmu_circ_0012122/mmu-miR-1843-5p/Sertad2, where mmu_circ_0012122 acts as a sponge for mmu-miR-1843-5p, leading to Sertad2 upregulation. This axis differentially modulated murine nerve cell fate: mmu_circ_0012122 knockdown reduced necrotic and non-viable apoptotic cells, while mmu-miR-1843-5p overexpression suppressed viable apoptosis and necrosis. Comprehensive characterization further identified Sertad2 as a key mediator promoting both nerve cell apoptosis and neuroinflammatory responses during infection. These findings underscored circRNAs as critical regulators of neuronal survival during RABV infection and highlighted the mmu_circ_0012122-driven network as a potential therapeutic target.
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Registered trials
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