Evidence map›Paper›PMID 42309221›Full record

ArticleOsteoarthritis and cartilage2026

Multimodal characterization of articular cartilage degeneration in the humeral head using Raman spectroscopy, biomechanics, and imaging.

Mason J Garcia, Dev R Mehrotra, Jake Giering, Erik E Ersland, Alberto Lalli, Giovanni Intermesoli, Shubham Laiwala, Olaia Rackauskas, Mario Keko, Prateek Misra and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mason J GarciaMusculoskeletal Translational Innovation Initiative, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Boston University, Mechanical Engineering Department, Boston, MA, USA. Electronic address: mjgarcia@bu.edu.
Dev R MehrotraBoston University, Department of Biomedical Engineering, Boston, MA, USA. Electronic address: dmehro@bu.edu.
Jake GieringBoston University, Department of Biomedical Engineering, Boston, MA, USA. Electronic address: jgiering@bu.edu.
Erik E ErslandBoston University, Mechanical Engineering Department, Boston, MA, USA.
Alberto LalliFondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy; Department of Medicine and Surgery, Research Unit of Orthopaedic and Trauma Surgery, Università Campus Bio-Medico di Roma, Roma, Italy. Electronic address: albertolalli30@gmail.com.
Giovanni IntermesoliFondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy; Department of Medicine and Surgery, Research Unit of Orthopaedic and Trauma Surgery, Università Campus Bio-Medico di Roma, Roma, Italy. Electronic address: giovanni.intermesoli@gmail.com.
Shubham LaiwalaMusculoskeletal Translational Innovation Initiative, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: slaiwala@bidmc.harvard.edu.
Olaia RackauskasMusculoskeletal Translational Innovation Initiative, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: olaiarackauskas@ufl.edu.
Mario KekoMusculoskeletal Translational Innovation Initiative, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Prateek MisraMusculoskeletal Translational Innovation Initiative, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: pmisra1@bidmc.harvard.edu.
Brian D SnyderMusculoskeletal Translational Innovation Initiative, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Boston University, Mechanical Engineering Department, Boston, MA, USA. Electronic address: snyderbd57@gmail.com.
Joseph P DeAngelisMusculoskeletal Translational Innovation Initiative, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: jpdeange@bidmc.harvard.edu.
Umile Giuseppe LongoFondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy; Department of Medicine and Surgery, Research Unit of Orthopaedic and Trauma Surgery, Università Campus Bio-Medico di Roma, Roma, Italy. Electronic address: g.longo@policlinicocampus.it.
Michael B AlbroBoston University, Mechanical Engineering Department, Boston, MA, USA; Boston University, Department of Biomedical Engineering, Boston, MA, USA. Electronic address: albro@bu.edu.
Arun J RamappaMusculoskeletal Translational Innovation Initiative, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: aramappa@bidmc.harvard.edu.
Ara NazarianMusculoskeletal Translational Innovation Initiative, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Boston University, Mechanical Engineering Department, Boston, MA, USA; Boston University, Department of Biomedical Engineering, Boston, MA, USA; Department of Orthopaedic Surgery, Yerevan State Medical University, Yerevan, Armenia. Electronic address: anazaria@bidmc.harvard.edu.

Funding

Arthroscopic Raman Monitoring of Cartilage Content for PTOA Diagnosis and Chondroregenerative Treatment ResponseR01AR081393 · NIAMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Michael B Albro, Brian D Snyder · 2022 to 2026
$2.8M
NIAMS NIH HHS R01 AR081393
6 · The paper itself

Abstract

objectiveThis study evaluated articular cartilage degeneration in the humeral head using a multimodal approach integrating Raman spectroscopy, mechanical testing, biochemical analysis, and micro-computed tomography (µCT). The goal was to identify sensitive biomarkers of early matrix-level degeneration that precede overt radiographic changes in glenohumeral osteoarthritis (OA).

methodsEleven humeral heads were collected from cadaveric shoulders and stratified by the presence of a focal chondral defect and rotator cuff (RC) tear status, yielding four specimens without visual cartilage degeneration (controls) and seven samples (3 RC + OA, 4 OA Only) with visual defects. Raman spectroscopy was used to non-destructively quantify the contents of cartilage glycosaminoglycan (GAG), collagen (COL), and water (H

resultsCartilage from degenerated regions exhibited decreased mechanical stiffness with a corresponding reduction in GAG and an increase in tissue hydration. Raman-derived GAG

conclusionCartilage degeneration in the glenohumeral joint is characterized by extracellular matrix (ECM) loss, increased hydration, compromised mechanical function, and alterations to the trabecular structure. Raman spectroscopy enabled the production of non-destructive spatial maps of tissue ECM composition, highlighting the progressive OA-associated changes in specimens with and without focal defects.

Indexed as

Cartilage, ArticularHumeral HeadOsteoarthritisAgedAged, 80 and overBiomechanical PhenomenaCadaverCollagenFemaleGlycosaminoglycansHumansMaleMiddle AgedRotator Cuff InjuriesShoulder JointSpectrum Analysis, RamanCollagenGlycosaminoglycansArticular cartilageCartilage biomechanicsExtracellular matrix degenerationGlenohumeral osteoarthritisHumeral headRaman spectroscopyRotator cuff tear

Identifiers

PMID42309221
PMCPMC13482738

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.