Evidence map›Paper›PMID 42310095›Full record

ArticleOncogene2026

Enhancing glioma immunotherapy by disrupting RBP-J-mediated NNMT signaling in tumor microenvironment.

Dan Zhang, Ning Guan, Xu Feng, Yanyun Wang, Lin Zhang, Jiabao Liu, Shoudan Zhang

Abstract read
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In one paragraph

Article in Oncogene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dan ZhangEndoscopy Center, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Ning GuanDepartment of Neurosurgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Xu FengDepartment of Neurosurgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Yanyun WangDepartment of Medical Oncology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.ORCID http://orcid.org/0009-0006-1044-5929
Lin ZhangDepartment of Medical Oncology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Jiabao LiuGraduate School, Jinzhou Medical University, Jinzhou, China.
Shoudan ZhangDepartment of Neurosurgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China. zhangshoudan1@126.com.ORCID http://orcid.org/0009-0009-6275-5285

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioma is a highly aggressive central nervous system malignancy characterized by profound immune evasion, the underlying mechanisms of which remain incompletely defined. This study investigated how the transcription factor RBP-J drives immune suppression through activation of NNMT in cancer-associated fibroblasts (CAFs). By integrating single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST), we identified a CAF-specific NNMT-high subpopulation enriched at the tumor margin and closely associated with M2 macrophages. Bioinformatic analyses using Seurat and Monocle3 delineated a stromal-immune regulatory network and highlighted RBP-J as a potential upstream regulator of NNMT. Mechanistic experiments demonstrated that RBP-J directly binds to the NNMT promoter and activates its transcription, leading to intracellular SAM depletion, reduced H3K27me3 levels, and epigenetic upregulation of SAA3. Elevated SAA3 promoted M2 macrophage recruitment and polarization, resulting in CD8

Indexed as

Brain NeoplasmsGliomaImmunoglobulin J Recombination Signal Sequence-Binding ProteinImmunotherapyTumor MicroenvironmentAnimalsCancer-Associated FibroblastsCell Line, TumorGene Expression Regulation, NeoplasticHumansMacrophagesMiceSignal TransductionImmunoglobulin J Recombination Signal Sequence-Binding ProteinRBPJ protein, human

Identifiers

PMID42310095

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.