GLP-1 Receptor Agonists in Reproductive Medicine: A Narrative Review and Investigational Pilot Survey of Patient Perspectives in Academic Reproductive Endocrinology.

Alexander L Vlasak, Palm Lindsey, Alexandra Minnihan, Alice Rhoton-Vlasak

Abstract readReview

In one paragraph

Review in Reproductive sciences (Thousand Oaks, Calif.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexander L VlasakDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.

Palm LindseyDepartment of Medicine, University of Colorado Anschutz, Denver, CO, USA.

Alexandra MinnihanDepartment of Obstetrics and Gynecology, University of Florida, Gainesville, FL, USA.

Alice Rhoton-VlasakDepartment of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Florida, Gainesville, FL, USA. rhotona@ufl.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This narrative review examines the emerging role of glucagon-like peptide-1 (GLP-1) receptor agonists in reproductive medicine, combining a narrative review of current literature with novel investigational pilot survey data from women seeking fertility care. The survey explores perceptions regarding weight, and weight loss methods including use or awareness of GLP-1. The integration of these perspectives reveals the potential for significant gaps between patient awareness and provider communication regarding these medications, while highlighting their potential therapeutic benefits for obesity-related infertility. A narrative literature review of GLP - 1 receptor agonists in reproductive medicine. An IRB approved anonymous investigational pilot survey to evaluate weight loss perceptions and methods used by those seeking care in a single academic infertility clinic. Narrative literature review with clinic recommendations was completed. Our findings demonstrate that while 86% of patients were aware of GLP-1 medications, only 19.3% had substantive discussions with healthcare providers despite 84.2% attempting weight loss in the past year. This disconnect occurs within a context where emerging evidence suggests GLP-1 receptor agonists may offer unique advantages for fertility optimization through weight loss, metabolic improvement, and potential direct reproductive effects.

Indexed as

Glucagon-Like Peptide-1 Receptor AgonistsInfertility, FemaleReproductive MedicineFemaleGlucagon-Like Peptide-1 ReceptorHealth Knowledge, Attitudes, PracticeHumansObesityPilot ProjectsWeight LossGlucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide-1 Receptor AgonistsClinical guidelinesGLP-1 receptor agonistsInfertilityObesity careUse surveyWeight loss

Identifiers

PMID42310245

DOI10.1111/dom.16110

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.