ArticleCommunications biology2026
A dermo-hypothalamic axis driven by TNF-α mediates sleep disturbances in psoriasis.
Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep disturbances are a debilitating feature of psoriasis, but whether they arise from itching or from direct effects of inflammation on the brain remains unclear. Here we show, using clinical data and a mouse model of psoriasis-like inflammation, that affected animals exhibit marked wakefulness and fragmented non-rapid eye movement sleep, even when itching is eliminated. This sleep disruption is linked to overactivity of wake-promoting neurons in a brain region called the anterior hypothalamic area. We find evidence of a local inflammatory response in this region, including activation of microglia and elevated levels of the signaling protein tumor necrosis factor-alpha. Directly delivering an inhibitor of this protein into the anterior hypothalamic area significantly restores normal sleep. These findings reveal a direct pathway from skin inflammation to sleep-regulating brain circuits and identify tumor necrosis factor-alpha as a potential target for treating insomnia in psoriasis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.