Evidence map›Paper›PMID 42310673›Full record

ArticleJournal of neuroinflammation2026

Microglial IRF7-induced lipophagy impairment aggravates lipid droplet overload and impedes neurological recovery after ischemic stroke.

Jing Yin, Yan Li, Yu-Lu Miao, Xue-Fang Song, Yao Cheng, Yu-Jie Zhai, Jia Ren, Cai-Hong Yang, Hui-Feng Zhang, Xiang-Nan Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jing Yin *Department of Pharmacology, Shanxi Key Laboratory of Metabolic-Immune Homeostasis and Drug Innovation, Shanxi Medical University, Jinzhong, 030600, China.
Yan Li *Department of Pharmacology, Shanxi Key Laboratory of Metabolic-Immune Homeostasis and Drug Innovation, Shanxi Medical University, Jinzhong, 030600, China.
Yu-Lu Miao *Department of Pharmacology, Shanxi Key Laboratory of Metabolic-Immune Homeostasis and Drug Innovation, Shanxi Medical University, Jinzhong, 030600, China.
Xue-Fang SongDepartment of Pharmacology, Shanxi Key Laboratory of Metabolic-Immune Homeostasis and Drug Innovation, Shanxi Medical University, Jinzhong, 030600, China.
Yao ChengDepartment of Pharmacology, Shanxi Key Laboratory of Metabolic-Immune Homeostasis and Drug Innovation, Shanxi Medical University, Jinzhong, 030600, China.
Yu-Jie ZhaiDepartment of Pharmacology, Shanxi Key Laboratory of Metabolic-Immune Homeostasis and Drug Innovation, Shanxi Medical University, Jinzhong, 030600, China.
Jia RenDepartment of Pharmacology, Shanxi Key Laboratory of Metabolic-Immune Homeostasis and Drug Innovation, Shanxi Medical University, Jinzhong, 030600, China.
Cai-Hong YangDepartment of Pharmacology, Shanxi Key Laboratory of Metabolic-Immune Homeostasis and Drug Innovation, Shanxi Medical University, Jinzhong, 030600, China.
Hui-Feng ZhangDepartment of Pharmacology, Shanxi Key Laboratory of Metabolic-Immune Homeostasis and Drug Innovation, Shanxi Medical University, Jinzhong, 030600, China.
Xiang-Nan ZhangInstitute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. xiangnan_zhang@zju.edu.cn.
Li-Jun YangDepartment of Pharmacology, Shanxi University of Medicine, Fenyang, 032200, China. yanglijunmm@126.com.
Yan-Ying FanDepartment of Pharmacology, Shanxi Key Laboratory of Metabolic-Immune Homeostasis and Drug Innovation, Shanxi Medical University, Jinzhong, 030600, China. fyanying6@hotmail.com.ORCID http://orcid.org/0000-0002-1021-1800

Funding

Four "batches" Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province 2023XM035National Natural Science Foundation of China 81872854Natural Science Foundation of Shanxi Province 202303021211118Science and Technology Innovation Team of Shanxi Province 202204051002030Science and Technology Innovation Team of Shanxi Province 202304051001039
6 · The paper itself

Abstract

Lipid droplet (LD) accumulation in microglia results in a dysfunctional and proinflammatory state after ischemic stroke and worsens neurological outcomes; yet how this accumulation is regulated remains unclear. Interferon regulatory factor 7 (IRF7) is an immune regulatory factor whose role in lipid metabolism and autophagy has been increasingly studied in peripheral tissues. However, the role of IRF7 in microglial lipophagy (a selective autophagic process that targets LDs) and poststroke functional recovery remains unexplored. In this study, using a mouse photothrombotic ischemia (PTI) model, we observed that microglia in the peri-infarct region displayed persistent lipophagy impairment and LD accumulation for up to 21 days. Reanalysis of the single-cell RNA sequencing (scRNA-seq) dataset revealed that an Irf7

Indexed as

AutophagyInterferon Regulatory Factor-7Ischemic StrokeLipid DropletsMicrogliaRecovery of FunctionAnimalsLipid MetabolismMaleMiceMice, Inbred C57BLMice, KnockoutInterferon Regulatory Factor-7Irf7 protein, mouseIRF7Lipid dropletLipophagy impairmentMicrogliaSTINGStroke

Identifiers

PMID42310673
PMCPMC13508275

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.