Evidence map›Paper›PMID 42310974›Full record

Trial reportAlcohol, clinical & experimental research2026

The Effects of Personalized Feedback About ALDH2*2, Alcohol Use, and Associated Health Risks on Drinking Intention and Consumption: The Role of Self-Efficacy and Perceived Threat.

Emily B Saldich, Christopher R Beam, Mark H C Lai, John R Monterosso, Kyla-Rose Walden, Christian S Hendershot, Katie Witkiewitz, Julie O Culver, Susan E Luczak

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alcohol, clinical & experimental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04967599 (Alcohol Metabolism and Disease Risk in Asians), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04967599 nacompletednot on this map

Alcohol Metabolism and Disease Risk in Asians: Examining the Impact of Personalized Phenotypic/Genotypic Feedback and Motivational Processes on Early Drinking Trajectories

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2021 to 2023Enrolled360ConditionsHealthyArmsPhenotype Feedback Intervention, Genotype Feedback Intervention
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emily B SaldichDepartment of Psychology, University of Southern California, Los Angeles, California, USA.
Christopher R BeamDepartment of Psychology, University of Southern California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0001-6827-409X
Mark H C LaiDepartment of Psychology, University of Southern California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-9196-7406
John R MonterossoDepartment of Psychology, University of Southern California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-5613-3182
Kyla-Rose WaldenDepartment of Psychology, University of Southern California, Los Angeles, California, USA.
Christian S HendershotDepartment of Population and Public Health Sciences and Institute for Addiction Science, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-5328-2035
Katie WitkiewitzDepartment of Psychology, Center on Alcohol, Substance Use, and Addictions, University of New Mexico, Albuquerque, New Mexico, USA.ORCID https://orcid.org/0000-0002-1086-3067
Julie O CulverNorris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
Susan E LuczakDepartment of Psychology, University of Southern California, Los Angeles, California, USA.

Funding

Alcohol metabolism and disease risk in Asians: Examining the impact of personalized phenotypic/genotypic feedback on early drinking trajectoriesR01AA032036 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Susan E. Luczak · 2025 to 2026
$1.5M
Alcohol metabolism and disease risk in Asians: Examining the impact of personalized phenotypic/genotypic feedback and motivational processes on early drinking trajectoriesR21AA028365 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LUCZAK, SUSAN E · 2021 to 2022
$433k
NIAAA NIH HHS R01 AA032036NIAAA NIH HHS R01AA032036NIAAA NIH HHS R21 AA028365NIAAA NIH HHS R21AA028365
6 · The paper itself

Abstract

backgroundThe genetic variant ALDH2*2, associated with alcohol-related flushing, is a risk factor for alcohol-related health problems. The public has been largely unaware of these risks, suggesting potential for educational interventions to reduce harms among at-risk individuals. Self-efficacy and threat perception are mechanisms of health behavior change that may explain discrepancies in how people respond to health risk information. In the current pilot study, we examined the effects of a brief feedback intervention about the health risks related to flushing, ALDH2*2, and alcohol use on participants' intention to change their drinking and their past-month heaviest week drinking quantity. We also evaluated whether self-efficacy and threat perception related to intention to change drinking.

methodsWe enrolled 360 Asian American undergraduates (58% female; age 17-25). Participants were randomized to view (1) phenotype feedback about the alcohol-related cancer risk associated with flushing and ALDH2*2 (PHEN), (2) PHEN plus their own ALDH2 genotype (PHEN+GENE), or (3) an attention control session (CONTROL). Participants who completed the feedback (n = 324) reported their intention to change their drinking post-feedback and their recent alcohol consumption, self-efficacy, and threat perception at baseline and 1-, 4-, 7-, and 10-month post-feedback.

resultsThose in PHEN+GENE had significantly higher intention to change drinking compared with those in CONTROL regardless of ALDH2*2 status. A significant interaction was found between self-efficacy and threat perception in predicting intention to change drinking. Higher intention to change drinking did not relate to decreased heaviest week drinking quantity.

conclusionsReceiving risk feedback was associated with greater intention to change drinking among both ALDH2*2(+) and ALDH2*2(-) participants, but intention to change was not found to be associated with a decrease in heaviest week drinking quantity. Future work in larger samples will further examine self-efficacy and threat perception as potential mechanisms underlying participants' intention to change their drinking behavior.

trial registrationClinicalTrials.gov: NCT04967599.

Indexed as

Alcohol DrinkingAldehyde Dehydrogenase, MitochondrialIntentionSelf EfficacyAdolescentAdultAsianFemaleFlushingHumansMalePilot ProjectsRisk FactorsYoung AdultAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanalcohol useALDH2brief interventionflushinghealth behavior changeself‐efficacy

Identifiers

PMID42310974
PMCPMC13475241

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.