Evidence map›Paper›PMID 42311150›Full record

ArticleAnnals of medicine2026

Combined effects of maternal periconceptional environmental exposures and infant cardiac transcription factor polymorphisms on congenital heart disease risk.

Jianhui Wei, Peng Huang, Letao Chen, Tubao Yang, Tingting Wang, Ziye Li, Lizhang Chen, Jiabi Qin

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Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jianhui WeiDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Peng HuangThe First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
Letao ChenDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Tubao YangDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Tingting WangDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Ziye LiDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Lizhang ChenDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.ORCID 0000-0001-5426-0519
Jiabi QinDepartment of Epidemiology and Health Statistics, School of Public Health, Kunming Medical University, Kunming, Yunnan, China.ORCID 0000-0002-9360-4991

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCongenital heart disease (CHD) is a leading cause of neonatal morbidity and mortality, with a complex aetiology involving genetic and environmental factors. Cardiac transcription factors, such as

methodsA hospital-based case-control study analyzed 585 CHD cases and 600 controls. Associations between transcription factor gene polymorphisms, maternal environmental exposures and CHD risk were assessed using logistic regression, multiplicative interaction models and model-based multifactor dimensionality reduction.

resultsSeveral transcription factor gene polymorphisms were significantly associated with CHD risk. Specifically,

conclusionInfant

Indexed as

GATA4 Transcription FactorHeart Defects, CongenitalMaternal ExposurePrenatal Exposure Delayed EffectsT-Box Domain ProteinsTranscription FactorsAdultCase-Control StudiesDevelopmental Origins of Health and DiseaseEnvironmental ExposureFemaleGene-Environment InteractionGenetic Predisposition to DiseaseHomeobox Protein Nkx-2.5HumansInfantGATA4 protein, humanGATA4 Transcription FactorHomeobox Protein Nkx-2.5NKX2-5 protein, humanT-Box Domain ProteinsT-box transcription factor 5Transcription Factorscardiac transcription factorCongenital heart diseasegene-environment interactiongene-gene interactiongene polymorphisms

Identifiers

PMID42311150
PMCPMC13288541

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.