ArticleBiomedical optics express2026
Dynamic speckle, reduced extinction, and multiple scattering in holographic optical coherence imaging.
Article in Biomedical optics express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Holographic optical coherence imaging (HOCI) records depth-resolved complex fields in a wide-field geometry, making temporal speckle a useful but path-mixed observable. This study presents an operational HOCI framework that links tumor-spheroid fluctuation descriptors to bead-phantom attenuation and residual-reflectivity measurements under defined exposure and sampling conditions. Reduced-extinction and transport-mean-free-path estimates identify when coherence-gated profiles depart from shallow single-scattering behavior. Size-varied bead suspensions show strongest path mixing for nominal 0.50 µm preparations, whereas 0.05 µm suspensions remain closest to the single-scattering limit. The results define practical depth ranges and fitting criteria for interpreting HOCI dynamics in optically dense samples.
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