Evidence map›Paper›PMID 42311701›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Copper isotope shifts in biofluids track Alzheimer's pathology.

Esther Lahoud, Frédéric Moynier, Brandon Mahan, Tu-Han Luu, Dimitri Rigoussen, Marie Le Borgne, Claire Paquet, Christopher Fowler, Ashley I Bush

Abstract read
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In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Esther LahoudUniversité Paris Cité Institut de Physique du Globe de Paris, CNRS Paris France.ORCID https://orcid.org/0009-0007-3009-3235
Frédéric MoynierUniversité Paris Cité Institut de Physique du Globe de Paris, CNRS Paris France.ORCID https://orcid.org/0000-0003-4321-5581
Brandon MahanMelbourne Analytical Geochemistry, School of Geography, Earth and Atmospheric Sciences The University of Melbourne Victoria Australia.
Tu-Han LuuUniversité Paris Cité Institut de Physique du Globe de Paris, CNRS Paris France.
Dimitri RigoussenUniversité Paris Cité Institut de Physique du Globe de Paris, CNRS Paris France.
Marie Le BorgneUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, LVTS, F-75018 Paris France.
Claire PaquetUniversité Paris Cité Centre de Neurologie Cognitive, GHU APHP Nord Hôpital Lariboisière Fernand-Widal GHU Nord APHP Inserm 1144, IHU Paris France.
Christopher FowlerFlorey Neuroscience Institute and Florey Department of Neuroscience and Mental Health The University of Melbourne Victoria Australia.
Ashley I BushFlorey Neuroscience Institute and Florey Department of Neuroscience and Mental Health The University of Melbourne Victoria Australia.ORCID https://orcid.org/0000-0001-8259-9069

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAltered copper metabolism has been reported in Alzheimer's disease (AD), with

methodsWe analyzed copper isotope composition in human cerebrospinal fluid (CSF) and serum from AD patients and controls using multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) and single quadrupole inductively coupled plasma mass spectrometry (SQ-ICP-MS). Samples included 22 CSFs (10 AD, 12 controls), 54 sera (28 AD, 26 controls).

resultsAD CSF was enriched in DISCUSSION: Copper isotope excursions in brain parenchyma are mirrored in CSF and serum. These shifts reflect amyloid pathology and highlight isotopic copper analysis as a potential minimally invasive biomarker for AD.

Indexed as

Alzheimer's diseaseamyloidbiometalscerebrospinal fluid (CSF)copperisotopeserum

Identifiers

PMID42311701
PMCPMC13269005

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.