ArticleFrontiers in genetics2026
Genetic variation at the IL-18-137C>G is associated with poor sepsis prognosis and enhanced inflammatory responses: a multicenter hospital-based study.
Article in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Sepsis is a life-threatening condition caused by dysregulated immune responses, leading to inflammation, tissue damage, and organ failure. This study investigates the role of the IL-18 rs187238 (-137C>G) polymorphism in sepsis susceptibility, progression, and patient prognosis. Methods: A multicenter case-control study was conducted with 784 sepsis patients and 776 healthy controls. The IL-18 rs187238 polymorphism was genotyped using imLDR™ multiplex SNP genotyping method. ELISA and qRT-PCR were used to detect related inflammatory cytokine expression, while functional analysis was performed using dual-luciferase assays to evaluate the impact of the rs187238 variant on IL-18 promoter activity. Results: We observed a significant association between the rs187238 polymorphism and 28-day ICU mortality in sepsis patients. The CG/GG genotypes (OR = 1.470, 95% CI = 1.029-2.129, Conclusion: The IL-18 rs187238 C>G polymorphism is linked to higher IL-18 expression and intensified inflammatory responses, which are associated with poor sepsis prognosis. The sepsis-associated risk rs187238-G allele serves as a potential prognostic biomarker for sepsis-related mortality. Targeting IL-18 or its genetic variations might offer new avenues for sepsis therapy.
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