Evidence map›Paper›PMID 42311766›Full record

ArticleFrontiers in cardiovascular medicine2026

Personalized polygenic profiling based on the genetic architecture of lipid metabolism in the Russian population.

Aleksandra Mamchur, Maria Bruttan, Veronika Daniel, Daria Kashtanova, Elena Zelenova, Irina Dzhumaniiazova, Mikhail Ivanov, Lorena Matkava, Olga Blinova, Sergey Mitrofanov and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Aleksandra MamchurFederal State Budgetary Institution «Centre for Strategic Planning and Management of Biomedical Health Risks» of the Federal Medical and Biological Agency (Centre for Strategic Planning, of the Federal Medical and Biological Agency), Moscow, Russia.
Maria BruttanFederal State Budgetary Institution «Centre for Strategic Planning and Management of Biomedical Health Risks» of the Federal Medical and Biological Agency (Centre for Strategic Planning, of the Federal Medical and Biological Agency), Moscow, Russia.
Veronika DanielFederal State Budgetary Institution «Centre for Strategic Planning and Management of Biomedical Health Risks» of the Federal Medical and Biological Agency (Centre for Strategic Planning, of the Federal Medical and Biological Agency), Moscow, Russia.
Daria KashtanovaFederal State Budgetary Institution «Centre for Strategic Planning and Management of Biomedical Health Risks» of the Federal Medical and Biological Agency (Centre for Strategic Planning, of the Federal Medical and Biological Agency), Moscow, Russia.
Elena ZelenovaFederal State Budgetary Institution «Centre for Strategic Planning and Management of Biomedical Health Risks» of the Federal Medical and Biological Agency (Centre for Strategic Planning, of the Federal Medical and Biological Agency), Moscow, Russia.
Irina DzhumaniiazovaFederal State Budgetary Institution «Centre for Strategic Planning and Management of Biomedical Health Risks» of the Federal Medical and Biological Agency (Centre for Strategic Planning, of the Federal Medical and Biological Agency), Moscow, Russia.
Mikhail IvanovFederal State Budgetary Institution «Centre for Strategic Planning and Management of Biomedical Health Risks» of the Federal Medical and Biological Agency (Centre for Strategic Planning, of the Federal Medical and Biological Agency), Moscow, Russia.
Lorena MatkavaFederal State Budgetary Institution «Centre for Strategic Planning and Management of Biomedical Health Risks» of the Federal Medical and Biological Agency (Centre for Strategic Planning, of the Federal Medical and Biological Agency), Moscow, Russia.
Olga BlinovaFederal State Budgetary Institution «Centre for Strategic Planning and Management of Biomedical Health Risks» of the Federal Medical and Biological Agency (Centre for Strategic Planning, of the Federal Medical and Biological Agency), Moscow, Russia.
Sergey MitrofanovFederal State Budgetary Institution «Centre for Strategic Planning and Management of Biomedical Health Risks» of the Federal Medical and Biological Agency (Centre for Strategic Planning, of the Federal Medical and Biological Agency), Moscow, Russia.
Liliya GolubnikovaFederal State Budgetary Institution «Centre for Strategic Planning and Management of Biomedical Health Risks» of the Federal Medical and Biological Agency (Centre for Strategic Planning, of the Federal Medical and Biological Agency), Moscow, Russia.
Naiana KumarFederal State Budgetary Institution «Centre for Strategic Planning and Management of Biomedical Health Risks» of the Federal Medical and Biological Agency (Centre for Strategic Planning, of the Federal Medical and Biological Agency), Moscow, Russia.
Ekaterina MaralovaFederal State Budgetary Institution «Centre for Strategic Planning and Management of Biomedical Health Risks» of the Federal Medical and Biological Agency (Centre for Strategic Planning, of the Federal Medical and Biological Agency), Moscow, Russia.
Andrey ShingalievFederal State Budgetary Institution «Centre for Strategic Planning and Management of Biomedical Health Risks» of the Federal Medical and Biological Agency (Centre for Strategic Planning, of the Federal Medical and Biological Agency), Moscow, Russia.
Marat EzhovFederal State Budgetary Institution «National Medical Research Center for Cardiology Named After Academician Yevgeniy Chazov» of the Ministry of Health of the Russian Federation, Moscow, Russia.
Aleksey MeshkovFederal State Budgetary Institution «National Medical Research Center for Cardiology Named After Academician Yevgeniy Chazov» of the Ministry of Health of the Russian Federation, Moscow, Russia.
Uliana ChubykinaFederal State Budgetary Institution «National Medical Research Center for Cardiology Named After Academician Yevgeniy Chazov» of the Ministry of Health of the Russian Federation, Moscow, Russia.
Olga PogorelovaFederal State Budgetary Institution «National Medical Research Center for Cardiology Named After Academician Yevgeniy Chazov» of the Ministry of Health of the Russian Federation, Moscow, Russia.
Mariia TripotenFederal State Budgetary Institution «National Medical Research Center for Cardiology Named After Academician Yevgeniy Chazov» of the Ministry of Health of the Russian Federation, Moscow, Russia.
Tatyana BalahonovaFederal State Budgetary Institution «National Medical Research Center for Cardiology Named After Academician Yevgeniy Chazov» of the Ministry of Health of the Russian Federation, Moscow, Russia.
Alexandra ViskovaFederal State Budgetary Institution «National Medical Research Center for Cardiology Named After Academician Yevgeniy Chazov» of the Ministry of Health of the Russian Federation, Moscow, Russia.
Madina KomarovaFederal State Budgetary Institution «National Medical Research Center for Cardiology Named After Academician Yevgeniy Chazov» of the Ministry of Health of the Russian Federation, Moscow, Russia.
Timur GurtsievFederal State Budgetary Institution «National Medical Research Center for Cardiology Named After Academician Yevgeniy Chazov» of the Ministry of Health of the Russian Federation, Moscow, Russia.
Natalia GomyranovaFederal State Budgetary Institution «National Medical Research Center for Cardiology Named After Academician Yevgeniy Chazov» of the Ministry of Health of the Russian Federation, Moscow, Russia.
Yulia VorobevaFederal State Budgetary Institution «National Medical Research Center for Cardiology Named After Academician Yevgeniy Chazov» of the Ministry of Health of the Russian Federation, Moscow, Russia.
Anastasia HotulevaFederal State Budgetary Scientific Institution «Izmerov Research Institute of Occupational Health», Moscow, Russia.
Maria KolyaskinaFederal State Budgetary Scientific Institution «Izmerov Research Institute of Occupational Health», Moscow, Russia.
Vladimir YudinFederal State Budgetary Institution «Centre for Strategic Planning and Management of Biomedical Health Risks» of the Federal Medical and Biological Agency (Centre for Strategic Planning, of the Federal Medical and Biological Agency), Moscow, Russia.
Valentin MakarovFederal State Budgetary Institution «Centre for Strategic Planning and Management of Biomedical Health Risks» of the Federal Medical and Biological Agency (Centre for Strategic Planning, of the Federal Medical and Biological Agency), Moscow, Russia.
Anton KeskinovFederal State Budgetary Institution «Centre for Strategic Planning and Management of Biomedical Health Risks» of the Federal Medical and Biological Agency (Centre for Strategic Planning, of the Federal Medical and Biological Agency), Moscow, Russia.
Lyudmila KuzminaFederal State Budgetary Scientific Institution «Izmerov Research Institute of Occupational Health», Moscow, Russia.
Sergey BoytsovFederal State Budgetary Institution «National Medical Research Center for Cardiology Named After Academician Yevgeniy Chazov» of the Ministry of Health of the Russian Federation, Moscow, Russia.
Sergey YudinFederal State Budgetary Institution «Centre for Strategic Planning and Management of Biomedical Health Risks» of the Federal Medical and Biological Agency (Centre for Strategic Planning, of the Federal Medical and Biological Agency), Moscow, Russia.
Veronika SkvortsovaThe Federal Medical Biological Agency (FMBA of Russia), Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Elevated cholesterol levels are associated with the risk of the most socially significant cardiovascular diseases, such as atherosclerosis, ischemic heart disease, and myocardial infarction. Methods: In this study, we sought to study the genetic architecture of lipid metabolism by conducting genome-wide association studies of total cholesterol, LDL-C, and HDL-C levels in a sample of the Russian population ( Results: A meta-analysis of the results of the conducted genome-wide association studies showed that total cholesterol and LDL-C were largely associated with the same variants located in the Conclusion: The models developed in this study consider age and a modifiable factor, BMI. Therefore, the personalized polygenic profiling approach presented in this study enables life-long CVD risk assessment.

Indexed as

cholesteroldyslipidemiaGWASHDLLDLpolygenic score (PGS)

Identifiers

PMID42311766
PMCPMC13269230

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.