Evidence map›Paper›PMID 42312160›Full record

ReviewACS pharmacology & translational science2026

Unveiling the Role of Glutathione

Manisha Nigam, Shivangi Kukreti, Sudarshan Singh, Abhay Prakash Mishra

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ACS pharmacology & translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Manisha NigamDepartment of Biochemistry, Hemvati Nandan Bahuguna Garhwal University, Srinagar Garhwal, 246174 Uttarakhand, India.
Shivangi KukretiDepartment of Biochemistry, Hemvati Nandan Bahuguna Garhwal University, Srinagar Garhwal, 246174 Uttarakhand, India.
Sudarshan SinghOffice of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand.
Abhay Prakash MishraCosmetics and Natural Products Research Centre (CosNat), Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.ORCID https://orcid.org/0000-0002-2224-0852

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer remains one of the most prevalent malignancies among women worldwide. Current therapeutic strategies comprising surgery, radiation therapy, immunotherapy, and postoperative chemotherapy have significantly improved patient outcomes. However, the emergence of multidrug resistance (MDR) continues to impede treatment efficacy. Several factors contribute to MDR, including drug inactivation, enhanced metabolism, transporter protein-mediated drug efflux, and epigenetic alterations. Among these, the overexpression of drug-metabolizing enzymes such as glutathione

Indexed as

breast cancerchemotherapydrug resistanceglutathione S-transferaseGST inhibitorsmultidrug resistance (MDR)prodrugstumor microenvironment

Identifiers

PMID42312160
PMCPMC13270447

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.