ArticleACS pharmacology & translational science2026
Sertraline Enhances Bacterial Control without Adversely Affecting the Pharmacodynamic-Pharmacokinetic Properties of Frontline Tuberculosis Drugs.
Article in ACS pharmacology & translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Host-directed therapies (HDTs) are gaining importance as innovative intervention strategies for shortening the treatment durations of tuberculosis (TB), a major public health burden. The combination of TB drugs and sertraline (SRT), an FDA-approved antidepressant, has shown promise in reducing the treatment duration and advancing tissue recovery in murine models. This study evaluates sertraline as an adjunct in the guinea pig model of infection that mimics human variability and its impact on TB drug pharmacokinetics (PK). Random-bred guinea pigs infected with
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