Evidence map›Paper›PMID 42312244›Full record

ArticleCell press blue2026

Strain transmission links human microbiomes along the oral-gut axis and across cohabiting individuals.

Vitor Heidrich, Gloria Fackelmann, Liviana Ricci, Roan Spadazzi, Gabriel Baldanzi, Michal Punčochář, Giulia Catassi, Paolo Marchi, Monica Modesto, Gianmarco Piccinno and 7 more

Abstract read
In one paragraph

Article in Cell press blue, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Vitor HeidrichDepartment of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
Gloria FackelmannDepartment of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
Liviana RicciDepartment of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
Roan SpadazziDepartment of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
Gabriel BaldanziDepartment of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
Michal PunčochářDepartment of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
Giulia CatassiDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Paolo MarchiDepartment of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
Monica ModestoDepartment of Agricultural and Food Sciences, University of Bologna, Bologna, Italy.
Gianmarco PiccinnoDepartment of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
Serena PorcariDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Debora RondinellaDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Francesco AsnicarDepartment of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
Mireia Valles-ColomerDepartment MELIS, Pompeu Fabra University, Barcelona, Spain.
Paola MattarelliDepartment of Agricultural and Food Sciences, University of Bologna, Bologna, Italy.
Gianluca IaniroDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Nicola SegataDepartment of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interpersonal strain transmission shapes the human microbiome, yet a comparative understanding of the transmission dynamics across body sites is lacking. We analyzed 1,644 paired oral and fecal metagenomes to investigate microbiome transmission among healthy cohabitants and intra-individual oral-gut overlap. Cohabitants shared significantly more oral and gut strains than non-cohabitants. Romantic partners exhibited the highest oral strain-sharing rates, exceeding their gut strain sharing. Higher oral transmissibility was associated with increased longitudinal strain replacement, while the most transmissible gut species were linked to poorer cardiometabolic health. Within individuals, 74.5% of cases of species detected in both sites involved the same strains, primarily related to abundant oral species such as

Indexed as

Bifidobacterium longumcohabitationgut microbiomemetagenomicsmicrobiome transmissionoral-gut axisoral microbiomeoral translocationstrain sharingstrain transmission

Identifiers

PMID42312244
PMCPMC13269251

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.