ArticleAnnals of medicine2026
Unveiling the cognitive fog in lung cancer patients: non-invasive exploration of blood-brain barrier disruption and brain structural changes.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundThis study investigates the correlation between blood-brain barrier (BBB) damage and cognitive impairment in patients suffering from untreated lung cancer. The study aims to understand the impact of BBB permeability on cognitive function and brain structure in this patient population. PATIENTS AND
methodsThis study included 104 lung cancer patients and 40 healthy individuals as controls. The permeability of the blood-brain barrier was evaluated using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). The study analyzed the correlation between BBB permeability and both brain structure and cognitive function to determine the extent of BBB damage's influence on cognitive impairment.
resultsThe study revealed a significant increase in BBB permeability among lung cancer patients, particularly in those experiencing cognitive impairment. Those with cognitive impairment exhibited a substantial decrease in cortical volume across several brain regions. Notably, the CONCLUSION(S): The findings indicate a strong association between BBB damage and cognitive impairment in lung cancer patients. DCE-MRI has shown promise as an effective diagnostic tool for assessing BBB damage in the context of lung cancer treatment. This research contributes novel insights into the pathophysiological mechanisms underlying cognitive impairment in lung cancer patients and provides valuable information for the development of personalized therapeutic strategies.
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