Evidence map›Paper›PMID 42313193›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society2026

A comprehensive full-length transcriptome atlas across multiple organs of an Indian yak breed-Arunachali.

Martina Pukhrambam, Kishor U Tribhuvan, Atrayee Dutta, Vijay Paul, Avinash Pandey, Dinamani Medhi, Mokhtar Hussain, Shubham Loat, Vijai Pal Bhadana, Suresh Dabas and 5 more

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Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Martina PukhrambamICAR-National Research Centre on Yak, Dirang, Arunachal Pradesh, 790101, India. martypukh@gmail.com.ORCID https://orcid.org/0000-0003-3517-5495
Kishor U TribhuvanICAR-Indian Institute of Agricultural Biotechnology, Ranchi, Jharkhand, 834003, India.
Atrayee DuttaICAR-National Research Centre on Yak, Dirang, Arunachal Pradesh, 790101, India.
Vijay PaulICAR-National Research Centre on Yak, Dirang, Arunachal Pradesh, 790101, India.
Avinash PandeyICAR-Indian Institute of Agricultural Biotechnology, Ranchi, Jharkhand, 834003, India.
Dinamani MedhiICAR-National Research Centre on Yak, Dirang, Arunachal Pradesh, 790101, India.
Mokhtar HussainICAR-National Research Centre on Yak, Dirang, Arunachal Pradesh, 790101, India.
Shubham LoatICAR-National Research Centre on Yak, Dirang, Arunachal Pradesh, 790101, India.
Vijai Pal BhadanaICAR-Indian Institute of Agricultural Biotechnology, Ranchi, Jharkhand, 834003, India.
Suresh DabasICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh, 250001, India.
Joy DasICAR-Central Institute for Cotton Research, Nagpur, Maharashtra, 441108, India.
Vijay N WaghmareICAR-Central Institute for Cotton Research, Nagpur, Maharashtra, 441108, India.
A K MohantyICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh, 250001, India.
Sujay RakshitICAR-Indian Institute of Agricultural Biotechnology, Ranchi, Jharkhand, 834003, India.
Mihir SarkarICAR-National Research Centre on Yak, Dirang, Arunachal Pradesh, 790101, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Yak (Bos grunniens) is a high-altitude adapted bovine species native to the Himalayan and Tibetan plateau, thriving at elevations above 3000 m from msl under hypobaric hypoxia. Despite its remarkable physiological adaptations, a complete transcriptomic understanding across multiple organs remains limited. In this study, full-length transcriptome sequencing of 22 tissues was performed using PacBio Iso-Seq, generating over 200,000 high-quality non-redundant RNA transcripts. This dataset significantly improves yak genome annotation and reveals widespread isoform diversity, including thousands of novel transcripts and 4,319 high-confidence lncRNAs. Enrichment of key hypoxia-related pathways such as HIF-1, PI3K-Akt, AMPK, and TGF-β was observed, along with tissue-specific expression patterns in vascular, immune, and reproductive systems. These results provide a valuable multi-organ transcriptomic resource and offer new insights into the genetic mechanisms supporting high-altitude adaptation in yak.

Indexed as

TranscriptomeAdaptation, PhysiologicalAltitudeAnimalsBreedingCattleGene Expression ProfilingMolecular Sequence AnnotationOrgan Specificity

Identifiers

PMID42313193

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.