Evidence map›Paper›PMID 42314060›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Stiffness-Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG-TNS4 Signaling.

Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Biwen ZhuDepartment of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital and Medical School of Nantong University, Nantong, China.
Jian WanDepartment of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital and Medical School of Nantong University, Nantong, China.
Xue ZhangResearch Center of Clinical Medicine, Affiliated Hospital and Medical School of Nantong University, Nantong, China.
Jiashuai YanDepartment of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital and Medical School of Nantong University, Nantong, China.
Xi ChenDepartment of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital and Medical School of Nantong University, Nantong, China.
Xiaoqi GuanDepartment of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital and Medical School of Nantong University, Nantong, China.
Qianqian RenResearch Center of Clinical Medicine, Affiliated Hospital and Medical School of Nantong University, Nantong, China.
Tao YangDepartment of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital and Medical School of Nantong University, Nantong, China.
Di WuDepartment of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital and Medical School of Nantong University, Nantong, China.
Qingsong GuoDepartment of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital and Medical School of Nantong University, Nantong, China.
Yibing GuoResearch Center of Clinical Medicine, Affiliated Hospital and Medical School of Nantong University, Nantong, China.
Yuhua LuDepartment of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital and Medical School of Nantong University, Nantong, China.

Funding

National Natural Science Foundation of China 82173363Postgraduate Research & Practice Innovation Program of Jiangsu Province KYCX24_3595Postgraduate Research & Practice Innovation Program of Jiangsu Province KYCX24_3607
6 · The paper itself

Abstract

Liver metastasis remains the primary cause of death in pancreatic cancer. Collagen deposition by activated hepatic stellate cells (HSCs) generates a stiff fibrotic niche that favors metastatic colonization, yet the underlying mechanisms remain incompletely understood. Using stiffness-tunable hydrogels, it is shown that elevated substrate stiffness activates HSCs and establishes a self-reinforcing loop of matrix stiffening. Mechanistically, stiffness triggers Piezo1-mediated Ca

Indexed as

Hepatic Stellate CellsLiver NeoplasmsPancreatic NeoplasmsAnimalsCell Line, TumorHumansIon ChannelsMiceSignal TransductionIon Channelsliver metastasismatrix stiffnesspancreatic ductal adenocarcinoma (PDAC)Piezo1‐GMFG‐TNS4 axis

Identifiers

PMID42314060
PMCPMC13337057

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.