ArticleBreast (Edinburgh, Scotland)2026
Effect of bariatric surgery timing on breast cancer incidence: Real-world evidence from TriNetX.
Article in Breast (Edinburgh, Scotland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeObesity increases the risk of breast cancer (BC), and bariatric surgery may lower overall cancer risk. However, the impact of sleeve gastrectomy (SG) timing on cancer outcomes remains unclear. PATIENTS AND
methodsUsing the TriNetX global health research network, we identified 4,439,072 women diagnosed with severe obesity (BMI >35 kg/m
resultsSG was associated with lower 5-year all-cause mortality across all timing groups compared to the control group. Early SG was significantly associated with a reduced 5-year incidence of BC (risk ratio [RR]: 0.799; 95% CI: 0.647 to 0.987; P = .037), gynecologic cancer (RR: 0.490; 95% CI: 0.378 to 0.635; P < .001), and metastasis (RR: 0.306; 95% CI: 0.230 to 0.408; P < .001). By contrast, delayed SG was associated with an increased risk of BC (RR: 1.404; 95% CI: 1.107 to 1.781; P = .005). Age-stratified analyses indicated that the association between SG timing and outcomes appeared more pronounced in patients aged ≥45 years.
conclusionsOur findings highlight the importance of timely bariatric surgery in optimizing both metabolic and oncologic outcomes, particularly in older women with obesity.
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