ArticleJACC. Advances2026
Triglyceride-Glucose-Waist-to-Height Ratio Index and Left Ventricular Diastolic Function in Military Athletes.
Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe triglyceride-glucose-waist-to-height ratio (TyG-WHtR) predicts heart failure, but its association with left ventricular diastolic function (LVDF) in physically fit individuals is unclear.
objectivesThis study aimed to assess whether TyG-WHtR independently associates with echocardiographic LVDF indicators and exercise performance in physically active military personnel.
methodsIn this cross-sectional analysis, 151 male and 25 female military personnel aged 18 to 44 years underwent biochemistry, echocardiography, and fitness testing (3-km run, push-ups, and sit-ups). Men were dichotomized at the median TyG-WHtR (3.954). Kendall correlations with bootstrap 95% CIs and Benjamini-Hochberg false discovery rate adjustment, plus theory-driven multivariable regression adjusted for age, sex, heart rate, atherogenic lipids, and TyG-WHtR, were used; multiplicative sex interaction was tested.
resultsHigher- vs lower-TyG-WHtR men (4.41 [4.13, 4.74] vs 3.62 [3.38, 3.82]) were older (29 [23, 36] vs 25 [21, 30] years), with adverse cardiometabolic profile, lower mitral e' velocity and E/A, and worse exercise performance. TyG-WHtR was age-independently correlated with e' velocity (τ -0.382; 95% CI: -0.462 to -0.297) and E/A (-0.265; -0.367 to -0.165), both Benjamini-Hochberg-adjusted P < 0.001. In regression, TyG-WHtR was the leading e' predictor (standardized β -0.367; -0.491 to -0.242). Sex × TyG-WHtR interaction on e' velocity was statistically detectable (P = 0.012) but underpowered.
conclusionsTyG-WHtR is age-independently associated with subclinical LVDF decline and lower exercise capacity in young, physically active military personnel. Whether insulin resistance reduction could improve diastolic function requires further study.
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