Evidence map›Paper›PMID 42314672›Full record

ArticleStem cell reports2026

Aging of hematopoietic stem cells is inconsequential to progenitor cell function.

Jenna Myers, Atesh K Worthington, Donna M Poscablo, Paloma Medina, Saran Chattopadhyaya, Raana Mogharrab, Marcel G E Rommel, E Camilla Forsberg

Abstract read
In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jenna MyersInstitute for the Biology of Stem Cells, University of California-Santa Cruz, Santa Cruz, CA 95064, USA; Program in Biomedical Science and Engineering, University of California-Santa Cruz, Santa Cruz, CA 95064, USA.
Atesh K WorthingtonInstitute for the Biology of Stem Cells, University of California-Santa Cruz, Santa Cruz, CA 95064, USA; Program in Biomedical Science and Engineering, University of California-Santa Cruz, Santa Cruz, CA 95064, USA.
Donna M PoscabloInstitute for the Biology of Stem Cells, University of California-Santa Cruz, Santa Cruz, CA 95064, USA; Program in Biomedical Science and Engineering, University of California-Santa Cruz, Santa Cruz, CA 95064, USA.
Paloma MedinaInstitute for the Biology of Stem Cells, University of California-Santa Cruz, Santa Cruz, CA 95064, USA; Department of Biomolecular Engineering, University of California-Santa Cruz, Santa Cruz, CA 95064, USA.
Saran ChattopadhyayaInstitute for the Biology of Stem Cells, University of California-Santa Cruz, Santa Cruz, CA 95064, USA; Department of Biomolecular Engineering, University of California-Santa Cruz, Santa Cruz, CA 95064, USA.
Raana MogharrabInstitute for the Biology of Stem Cells, University of California-Santa Cruz, Santa Cruz, CA 95064, USA; Program in Biomedical Science and Engineering, University of California-Santa Cruz, Santa Cruz, CA 95064, USA.
Marcel G E RommelInstitute for the Biology of Stem Cells, University of California-Santa Cruz, Santa Cruz, CA 95064, USA; Department of Biomolecular Engineering, University of California-Santa Cruz, Santa Cruz, CA 95064, USA.
E Camilla ForsbergInstitute for the Biology of Stem Cells, University of California-Santa Cruz, Santa Cruz, CA 95064, USA; Program in Biomedical Science and Engineering, University of California-Santa Cruz, Santa Cruz, CA 95064, USA; Department of Biomolecular Engineering, University of California-Santa Cruz, Santa Cruz, CA 95064, USA. Electronic address: cforsber@ucsc.edu.

Funding

UNIVERSITY OF CALIFORNIA, SANTA CRUZ IMSD PROGRAMR25GM058903 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI JURICA, MELISSA S · 1999 to 2019
$12.2M
Defining the cause and consequence of aging-specific platelet specification from hematopoietic stem cellsR01AG062879 · NIA · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CAMILLA FORSBERG · 2019 to 2026
$4.9M
Training Program/Molecular/Cell/Developmental BiologyT32GM008646 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STROME, SUSAN · 1999 to 2018
$3.7M
CytoFLEX LX Cell AnalyzerS10OD030423 · OD · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI FORSBERG, CAMILLA · 2021 to 2021
$297k
Defining regulators of hematopoietic stem cell self-renewal and lineage potentialF31HL151199 · NHLBI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI WORTHINGTON, ATESH K · 2020 to 2022
$115k
NHLBI NIH HHS F31 HL151199NIA NIH HHS R01 AG062879NIGMS NIH HHS R25 GM058903NIGMS NIH HHS T32 GM008646NIH HHS S10 OD030423
6 · The paper itself

Abstract

Aging of the hematopoietic system has profound consequences for organismal health and longevity, attributed to the well-characterized functional aging of hematopoietic stem cells (HSCs). Here, we tested whether progenitor cells may demonstrate age resistance to enable hematopoietic homeostasis throughout life despite the functional decline of upstream HSCs. Strikingly, our results revealed unwavering reconstitution capacity by young and old progenitors, demonstrating that intermediate progenitors are functionally unaffected by aging and placing Flk2+ multipotent progenitors (MPP

Indexed as

AgingCellular SenescenceHematopoietic Stem CellsAnimalsCell ProliferationHomeostasisMiceMitochondriaMultipotent Stem CellsTranscriptomeage resilienceagingaging homeostasishematopoietic progenitor cellshematopoietic reconstitutionhematopoietic stem cellslongevitymultipotent progenitor cellssingle-cell RNA sequencingtranscriptomicstransplantation

Identifiers

PMID42314672
PMCPMC13385444

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.