ReviewPlant cell reports2026
The dynamic landscape of plant DNA demethylation: mechanisms, functions, and environmental responses.
Review in Plant cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
DNA methylation is a fundamental epigenetic modification that regulates gene expression, maintains genome stability, and supports developmental programs in plants. Rather than being static, the plant methylome is highly dynamic and continuously shaped by the opposing activities of DNA methyltransferases and DNA demethylases. Active DNA demethylation, initiated by the DEMETER/REPRESSOR OF SILENCING 1 (DME/ROS1) family of 5-methylcytosine (5mC) DNA glycosylases, is a major mechanism for removing repressive methylation marks and facilitating transcriptional plasticity. This review summarizes current knowledge of the molecular machinery and regulatory networks underlying active DNA demethylation. It highlights multi-layered regulation of demethylases activity, including chromatin-based targeting, assembly of regulatory protein complexes, and transcriptional and post-translational control. We further discuss the roles of DNA demethylation in key developmental processes, including genomic imprinting, fruit ripening, and organogenesis. A major focus is its proposed role as an integrator of environmental signals, mediating plant responses to diverse biotic and abiotic stresses such as drought, salinity, temperature extremes, and pathogen infection. This review also examines crosstalk between DNA demethylation, phytohormone signaling, and metabolic pathways, as well as its roles in stress memory, epigenetic memory, and transgenerational epigenetic inheritance. Finally, we outline key unresolved questions, particularly those related to the mechanistic basis of locus-specific targeting and the stability of stress-induced epigenetic states, including epigenetic memory and transgenerational epigenetic inheritance, and discuss how precision epigenome engineering may provide opportunities to translate these mechanistic insights into targeted regulation of developmental and stress-responsive pathways, thereby advancing crop improvement and sustainable agriculture.
Indexed as
Identifiers
42315671What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.