Evidence mapPaperPMID 42316869Full record

Trial reportJournal of the International Society of Sports Nutrition2026

The impact of (poly)phenol-rich sugarcane extract intervention on markers of gastrointestinal integrity and systemic inflammation in response to exertional-heat stress.

Ulluwis H A J Hewawansa, Kayla Henningsen, Natália Vilela Silva Daniel, Sandra In, Giles Sugay, Michael J Houghton, Elizabeth Barber, Gary Williamson, Ricardo J S Costa

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ulluwis H A J HewawansaDepartment of Nutrition Dietetics & Food, Faculty of Medicine, Nursing and Health Sciences, Monash University, Notting Hill, VIC, Australia.ORCID 0000-0003-1837-4951
Kayla HenningsenDepartment of Nutrition Dietetics & Food, Faculty of Medicine, Nursing and Health Sciences, Monash University, Notting Hill, VIC, Australia.ORCID 0000-0002-0289-7857
Natália Vilela Silva DanielFaculdade de Ciências Aplicadas, Universidade Estadual de Campinas (FCA/UNICAMP), Limeira, São Paulo, Brazil.
Sandra InDepartment of Nutrition Dietetics & Food, Faculty of Medicine, Nursing and Health Sciences, Monash University, Notting Hill, VIC, Australia.
Giles SugayDepartment of Nutrition Dietetics & Food, Faculty of Medicine, Nursing and Health Sciences, Monash University, Notting Hill, VIC, Australia.
Michael J HoughtonDepartment of Nutrition Dietetics & Food, Faculty of Medicine, Nursing and Health Sciences, Monash University, Notting Hill, VIC, Australia.ORCID 0000-0001-6579-7995
Elizabeth BarberDepartment of Nutrition Dietetics & Food, Faculty of Medicine, Nursing and Health Sciences, Monash University, Notting Hill, VIC, Australia.ORCID 0000-0001-8972-6163
Gary WilliamsonDepartment of Nutrition Dietetics & Food, Faculty of Medicine, Nursing and Health Sciences, Monash University, Notting Hill, VIC, Australia.ORCID 0000-0002-5624-6267
Ricardo J S CostaDepartment of Nutrition Dietetics & Food, Faculty of Medicine, Nursing and Health Sciences, Monash University, Notting Hill, VIC, Australia.ORCID 0000-0003-3069-486X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExertional-heat stress (EHS) perturbs gastrointestinal integrity, leading to systemic inflammation that may warrant medical attention. The study aimed to determine the effects of a (poly)phenol-rich sugarcane extract (PRSE) beverage and gel interventions on biomarkers of intestinal epithelial integrity and systemic immune responses to an EHS challenge.

methodUsing a double-blind placebo-controlled design, participants (

resultsCompared with placebo, the PRSE trial exhibited higher rectal temperature (

conclusionTwo weeks of PRSE supplementation with a carbohydrate-containing beverage during EHS may provide modest advantages to intestinal epithelial integrity and systemic inflammatory, without further exacerbating Ex-GIS.

Indexed as

Gastrointestinal TractHeat Stress DisordersInflammationPhysical ExertionPlant ExtractsPolyphenolsSaccharumAdultBeveragesBiomarkersCytokinesDouble-Blind MethodFemaleHot TemperatureHumansHydrocortisoneBiomarkersCytokinesHydrocortisonePlant ExtractsPolyphenolsendotoxinExercise-induced gastrointestinal syndromegastrointestinal symptomsI-FABPpolyphenolrunning

Identifiers

PMID42316869
PMCPMC13288546

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.