Evidence map›Paper›PMID 42317007›Full record

ArticleAnnals of medicine2026

Multi-trajectories of serum uric acid/high density lipoprotein cholesterol ratio and fasting plasma glucose in chronic kidney disease.

Mingxuan Xie, Zhenghong Luo, Huixian Xiong, Juan Jiang, Yuping Liu, Shujin Guo, Xiaopeng Yao, Zhengwei Wan, Junlin Zhang, Ping Shuai

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Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Mingxuan XieDepartment of Health Management & Physical Examination, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Zhenghong LuoDepartment of Health Management & Physical Examination, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Huixian XiongSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Juan JiangDepartment of Health Management & Physical Examination, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Yuping LiuDepartment of Health Management & Physical Examination, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Shujin GuoDepartment of Health Management & Physical Examination, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Xiaopeng YaoSchool of Public Health, Southwest Medical University, Luzhou, China.
Zhengwei WanDepartment of Health Management & Physical Examination, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Junlin ZhangDepartment of Health Management & Physical Examination, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Ping ShuaiDepartment of Health Management & Physical Examination, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to investigate the associations of longitudinal trajectories of the serum uric acid to high-density lipoprotein cholesterol ratio (UHR) and fasting plasma glucose (FPG) with chronic kidney disease (CKD) risk.

methodsIn this retrospective cohort study, we included 7,541 adults who underwent at least three annual health examinations. Cox proportional hazards models were used to evaluate associations of UHR and FPG (in quartiles) with incident CKD. Group-based multi-trajectory modeling (GBMTM) was subsequently applied to identify distinct joint trajectories of UHR and FPG.

resultsDuring follow-up, 558 participants developed CKD (incidence 7.40%). In fully adjusted Cox models, higher UHR quartiles remained independently associated with increased CKD risk. The association for FPG was attenuated after full adjustment.GBMTM identified four joint trajectory groups: Group 1(low UHR-low FPG), Group 2(moderate UHR-moderate FPG), Group 3(moderate-high UHR with fluctuating moderate FPG), and Group 4(high UHR with fluctuating moderate FPG). Compared to Group 1, the adjusted hazard ratios (95% CI) for CKD were 1.34 (1.05 ∼ 1.70) for Group 2, 2.31 (1.73 ∼ 3.09) for Group 3, and 4.21 (2.88 ∼ 6.15) for Group 4. Subgroup analyses generally supported these findings.

conclusionsWhile elevated UHR is independently associated with the risk of developing CKD, the association for FPG was attenuated after full adjustment. The joint trajectory analysis highlights that their dynamic co-evolution is significantly associated with CKD risk, identifying a high-risk phenotype that may inform early risk stratification.

Indexed as

Blood GlucoseCholesterol, HDLRenal Insufficiency, ChronicUric AcidAdultAgedFastingFemaleHumansIncidenceMaleMiddle AgedProportional Hazards ModelsRetrospective StudiesRisk FactorsBlood GlucoseCholesterol, HDLUric AcidChronic kidney diseasefasting plasma glucoseGroup-based multi trajectory modelsserum uric acid/high density lipoprotein cholesterol ratio

Identifiers

PMID42317007
PMCPMC13288539

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.