ReviewFrontiers in bioengineering and biotechnology2026
Deciphering skin architecture, wound pathophysiology and molecular mechanisms of healing: insights into immune response and therapeutic strategies.
Review in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Probiotics and Extracellular Vesicles as Redox Modulators in Wound Healing: From Microbial Therapeutics to Engineered Nanotherapeutic Strategies.Antioxidants (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin not only serves as a protective barrier, but also as a dynamic immunological and sensory organ responsible for complex physiological processes. Disruption through trauma, surgery, burns or chronic metabolic disease initiates a tightly regulated healing cascade involving inflammatory signaling, extracellular matrix remodeling, angiogenesis and coordinated cellular responses. While acute wounds generally progress through orderly phases of repair, chronic wounds such as diabetic foot ulcers, venous ulcers and pressure injuries become arrested in persistent inflammatory states characterized by protease imbalance, senescent cell accumulation, impaired vascularization and colonization of microbial biofilms, contributing to significant global morbidity and healthcare burden. This review integrates structural biology, immune mechanisms and molecular signaling pathways that govern wound repair, clearly delineating the differences between acute and chronic healing. Particular emphasis is placed on inflammation-driven dysregulation, extracellular matrix dynamics and defective angiogenesis that underpin chronic wound pathology. Rare and often underrepresented wound types, including radiation-induced and autoimmune-associated lesions, are also discussed to provide a broader and clinically relevant perspective. Importantly, the review highlights translational and technological advances transforming wound management, including self-healing hydrogels, nanofiber scaffolds, bioactive and stimuli-responsive dressings, biosensor-integrated platforms, cellular and molecular therapies and AI-assisted diagnostic systems. These innovations exemplify a shift from passive wound coverage toward biointeractive, precision-guided and microenvironment-responsive therapeutic strategies. By bridging immunopathology, regenerative medicine, nanobiotechnology and digital health platforms within a single cohesive narrative, this review serves as a comprehensive and integrative resource for academicians, clinicians, translational researchers and pharmaceutical innovators seeking a mechanistically grounded yet application-oriented understanding of modern wound care.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.