SynthesisFrontiers in immunology2026
From empirical treatment to precision intervention: a multi-database bibliometric analysis of neuropsychiatric systemic lupus erythematosus (2006-2025).
Synthesis in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a severe and complex complication of systemic lupus erythematosus that affects diagnostic decision-making and treatment strategies. However, the temporal evolution of evidence-based diagnostic and therapeutic paradigms, as well as persistent clinical bottlenecks, has not been fully characterized. Methods: We conducted a comprehensive bibliometric analysis of 1,569 NPSLE-related publications retrieved from the Web of Science Core Collection and Scopus between 2006 and 2025. In addition, relevant clinical trials from PubMed were incorporated to support an evidence-based synthesis. Results: Over the past two decades, annual publication volume in the NPSLE field increased, with an average growth rate of 6.04%. China and the United States emerged as the leading global contributors. Collaboration patterns differed across countries: the United States had a multiple-country publication (MCP) rate of 23.6%, whereas China had a lower MCP rate of 7.5%. Keyword evolution indicated a paradigm shift toward precision diagnostics and therapeutics, with neuroimaging and cognitive assessment emerging as prominent research hotspots. Conclusions: Despite substantial advances, the field remains constrained by major challenges, including clinical heterogeneity, the lack of standardized diagnostic thresholds, and the systematic exclusion of patients with active NPSLE from many SLE clinical trials. Future work should prioritize standardized diagnostic frameworks, NPSLE-specific clinical trials, and the development of effective CNS-penetrant therapies to improve long-term patient outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.