Evidence map›Paper›PMID 42317332›Full record

ArticleFrontiers in immunology2026

Quercetin attenuates skin inflammation and fibrosis in systemic sclerosis by targeting the RELA/c-Jun axis to suppress th17 cell responses.

Xiangzhen Kong, Hiochon Leong, Min Du, Jingyi Yang, Jingzhen Lai, Ziying Dong, Menghua Hu, Yifei Gu, Yexin Li, Qiaorui Tan and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Xiangzhen Kong *Division of Rheumatology, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hiochon Leong *Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
Min Du *Department of Pathology, Huadong Hospital, Fudan University, Shanghai, China.
Jingyi Yang *State Key Laboratory of Genetics and Development of Complex Phenotypes, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
Jingzhen LaiState Key Laboratory of Genetics and Development of Complex Phenotypes, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
Ziying DongState Key Laboratory of Genetics and Development of Complex Phenotypes, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
Menghua HuState Key Laboratory of Genetics and Development of Complex Phenotypes, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
Yifei GuDepartment of Plastic and Aesthetic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Yexin LiFaculty of Applied Science, University of British Columbia, Vancouver, BC, Canada.
Qiaorui TanState Key Laboratory of Genetics and Development of Complex Phenotypes, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
Haiyan ChuState Key Laboratory of Genetics and Development of Complex Phenotypes, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
Qingmei LiuDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
Yanyun MaAcademy for Engineering & Technology, Fudan University, Shanghai, China.
Weihong XuDepartment of Clinical Laboratory, Shibei Hospital, Jing'an District, Shanghai, China.
Shanji LiState Key Laboratory of Genetics and Development of Complex Phenotypes, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
Yuxiao ChenState Key Laboratory of Genetics and Development of Complex Phenotypes, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
Dongdong ChenDivision of Rheumatology, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yuanyuan ChenDivision of Rheumatology, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wei LuDepartment of Stomatology, Hangzhou First People's Hospital, Hangzhou, China.
Jie ZhuAnesthesiology department of Shanghai Putuo Maternity and Infant Health Hospital, Shanghai, China.
Jiucun WangHuman Phenome Institute, Fudan University, Shanghai, China.
Lei WangDivision of Rheumatology, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Aberrant Th17 cell activation and interleukin-17 (IL-17) production drive skin inflammation and progressive fibrosis in systemic sclerosis (SSc). Identifying small molecules that can precisely modulate these pathogenic T cell responses is crucial for developing novel SSc therapies. Methods: We utilized primary CD4 Results: In patient-derived CD4 Conclusion: Our findings identify the RELA/c-Jun axis as a critical target for modulating T cell pathogenicity in SSc and suggest that quercetin holds therapeutic potential as an immunometabolic modulator to alleviate skin fibrosis.

Indexed as

DermatitisProto-Oncogene Proteins c-junQuercetinScleroderma, SystemicSkinTh17 CellsTranscription Factor RelAAnimalsBleomycinCytokinesDisease Models, AnimalFemaleFibrosisHumansInterleukin-17MaleBleomycinCytokinesInterleukin-17Proto-Oncogene Proteins c-junQuercetinTranscription Factor RelAc-junIL-17 signalingquercetinRelA (p65)skin fibrosissystemic sclerosisTh17 cells

Identifiers

PMID42317332
PMCPMC13272162

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.