Evidence map›Paper›PMID 42317388›Full record

ArticleiScience2026

Transcriptomic signatures of synaptic loss in Alzheimer's disease.

Lipeng Sun, Xinyuan Yang, Xiaomeng Xu, Lin Kang, Yingting Zheng, Qi Huang, Wei Xu, Yihui Guan, Yiwen Shen, Jun Liu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lipeng SunClinical Neuroscience Center, Ruijin Hospital LuWan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China.
Xinyuan YangClinical Neuroscience Center, Ruijin Hospital LuWan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China.
Xiaomeng XuClinical Neuroscience Center, Ruijin Hospital LuWan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China.
Lin KangDepartment of Neurology & Institute of Neurology, Ruijin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yingting ZhengDepartment of Neurology & Institute of Neurology, Ruijin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Qi HuangDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai 200040, China.
Wei XuDepartment of Neurology & Institute of Neurology, Ruijin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yihui GuanDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai 200040, China.
Yiwen ShenDepartment of Radiology, Ruijin Hospital LuWan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China.
Jun LiuDepartment of Neurology & Institute of Neurology, Ruijin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yulei DengClinical Neuroscience Center, Ruijin Hospital LuWan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China.
Shu LiuState Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Junfang ZhangDepartment of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Fang XieDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai 200040, China.
Binyin LiClinical Neuroscience Center, Ruijin Hospital LuWan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synaptic loss is a major pathological cause of cognitive impairment in Alzheimer's disease (AD). We integrated

Indexed as

biological sciences

Identifiers

PMID42317388
PMCPMC13272548

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.