ArticleAJOG global reports2026
A retrospective study of the relationship between low-density lipoprotein cholesterol and pregnancy outcomes after assisted reproductive technology treatments in women with diabetes mellitus and infertility.
Article in AJOG global reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis study aimed to investigate the role of low-density lipoprotein cholesterol as a key parameter in improving pregnancy outcomes after assisted reproductive technology treatments in women with diabetes mellitus.
objectiveTo investigate the relationship between low-density lipoprotein cholesterol and pregnancy outcomes after assisted reproductive technology treatments in women with diabetes and infertility. STUDY
design474 female patients diagnosed with diabetes were included in this study. The patients were divided into the high LDL-C group (≥3 mmol/L) and the low LDL-C group (<3 mmol/L). According to the protocol of ovarian stimulation, the clinical characteristics in ART cycles and pregnancy outcomes were compared separately. The data were analyzed after propensity score matching.
resultsIn the GnRH antagonist protocol group, there were no significant differences in baseline characteristics between the high- and low-LDL-C groups. Nevertheless, ART treatment characteristics and pregnancy outcomes did not differ significantly between the 2 groups (
conclusionThis study demonstrates that in infertile women with diabetes mellitus undergoing ART, elevated pretreatment LDL-C is a significant and modifiable marker associated with an increased risk of early miscarriage and a reduced live birth rate. The impact of LDL-C varies by ovarian stimulation protocol. These findings underscore the importance of integrating preconception lipid management into the clinical pathway and adopting a protocol-specific risk assessment to optimize pregnancy outcomes.
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