Evidence map›Paper›PMID 42317459›Full record

ReviewFrontiers in veterinary science2026

Multidimensional regulatory mechanisms of chicken immunity: focus on viral infection, intestinal microbiota and heat stress.

Yanhong Wang, Min Yang, Jingying Zhao, Hao Wu, Kun Wang, Dawei Sun, Ru Zhang, Zhiqiang Xu, Zhenhui Cao, Changrong Ge and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yanhong Wang *Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, Yunnan, China.
Min Yang *Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, Yunnan, China.
Jingying Zhao *Institute of Science and Technology, Chuxiong Normal University, Chuxiong, China.
Hao WuFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, Yunnan, China.
Kun WangFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, Yunnan, China.
Dawei SunYunnan Academy of Animal Husbandry and Veterinary Sciences, Kunming, Yunnan, China.
Ru ZhangYunnan Academy of Animal Husbandry and Veterinary Sciences, Kunming, Yunnan, China.
Zhiqiang XuCollege of Food Science and Technology, Yunnan Agricultural University, Kunming, Yunnan, China.
Zhenhui CaoFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, Yunnan, China.
Changrong GeFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, Yunnan, China.
Junjing JiaFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, Yunnan, China.
Lixian LiuInstitute of Science and Technology, Chuxiong Normal University, Chuxiong, China.
Zonghui JianFaculty of Animal Husbandry and Veterinary Medicine, Yunnan Vocational and Technical College of Agriculture, Kunming, Yunnan, China.
Tengfei DouFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, Yunnan, China.
Xiannian ZiFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, Yunnan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chickens are a vital dietary protein source globally, yet their immune function is increasingly compromised by interconnected challenges including breed specific genetic heterogeneity, viral infections, intestinal microbial dysbiosis, and environmental stressors-all of which hinder sustainable poultry production. The chicken immune system, anchored by central immune organs (bursa of Fabricius, thymus) and peripheral immune organs (spleen, lymph nodes), relies on the coordinated interplay of innate and adaptive immunity to fend off exogenous pathogens. However, the holistic regulatory networks linking genetic background, pathogenic pressure, microbial communities, and environmental cues in shaping chicken immunity remain incompletely resolved. Immune related gene polymorphisms (e.g., MHC-B, TLR4) underpin interbreed differences in immune response magnitude and specificity, while viral pathogens such as Newcastle Disease Virus (NDV) and infectious bursal disease virus (IBDV) disrupt T/B lymphocyte dynamics, alter the expression of immune regulatory microRNAs (miR-155, miR-21) and pro-/anti-inflammatory cytokines (IL-1β, IFN-

Indexed as

avian-specific immunitychickenheat stressimmune regulationintestinal microbiotapoultry disease controlviral immunosuppression

Identifiers

PMID42317459
PMCPMC13272130

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.