ArticleFrontiers in pediatrics2026
The effect of IV fluid supplementation and feeding method on bilirubin elimination in term neonates with severe indirect hyperbilirubinemia: a retrospective cohort study.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study aimed to assess the independent effects of intravenous (IV) fluid supplementation and different enteral feeding patterns on bilirubin elimination in healthy term neonates treated with intensive phototherapy for severe indirect hyperbilirubinemia. Materials and methods: This single-center, retrospective cohort study included 271 healthy term newborns who received phototherapy for indirect hyperbilirubinemia between 2023 and 2025. The neonates were divided into two groups: those receiving enteral feeding alone ( Results: The IV fluid supplementation group had significantly higher baseline total serum bilirubin (TSB) levels and postnatal age than the enteral feeding-only group ( Conclusion: In term neonates with severe indirect hyperbilirubinemia with no clinical evidence of dehydration, IV fluid supplementation appeared to provided no additional benefit in reducing bilirubin levels. Our findings suggest that enteral feeding patterns may have a greater influence on the response to phototherapy. Therefore, our findings suggest that routine IV fluid administration may not be necessary in the management of hyperbilirubinemia, and priority should be given to effective lactation support and enteral feeding. When breast milk intake is insufficient, formula supplementation should be considered as a temporary and supportive option to accelerate bilirubin elimination, however, due to the heterogeneity in feeding volumes, this effect should be interpreted cautiously.
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