Evidence map›Paper›PMID 42317867›Full record

ArticleFrontiers in nutrition2026

Folate deficiency correlates with severity of primary biliary cholangitis via modulating key regulatory genes.

Yujie Yan, Qie Mu, Bonan Li, Yuqing Sun, Hong Yang, Zhiqin Huang, Baofeng Yu, Li Zhang, Huifang Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yujie Yan *Department of Gastroenterology, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Qie Mu *Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, Shanxi, China.
Bonan LiSchool of Public Health, Shanxi Medical University, Taiyuan, Shanxi, China.
Yuqing SunDepartment of Hepatobiliary Surgery and Liver Transplant Center, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Hong YangDepartment of Hepatobiliary Surgery and Liver Transplant Center, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Zhiqin HuangThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Taiyuan, China.
Baofeng YuDepartment of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, Shanxi, China.
Li ZhangDepartment of Hepatobiliary Surgery and Liver Transplant Center, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Huifang HuangDepartment of Gastroenterology, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the association between serum folate and Primary biliary cholangitis (PBC) progression through clinical, transcriptomic, and protein-level analyses. Methods: Serum folate levels were measured in 90 patients with PBC and 90 healthy controls. RNA-sequencing (RNA-seq) was performed on three subgroups (PBC patients with normal folate, PBC patients with low folate, and controls), and six candidate genes were validated by enzyme-linked immunosorbent assay (ELISA). Results: Serum folate was significantly decreased in PBC patients, with further reduction in late-stage disease ( Conclusion: Serum folate is inversely correlated with PBC severity and may serve as a potential predictive biomarker. Folate deficiency likely contributes to PBC pathogenesis by modulating key genes, including ARID3B and MXD1.

Indexed as

biomarkerdisease progressionfolateprimary biliary cholangitistranscriptomic

Identifiers

PMID42317867
PMCPMC13271935

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.