ArticleFrontiers in endocrinology2026
Non-linear and context-dependent association of maternal BMI with cumulative live birth in Chinese women undergoing intrauterine insemination: a retrospective study of 3788 cycles.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Evidence regarding maternal body mass index (BMI) and intrauterine insemination (IUI) outcomes remains controversial. This study aimed to evaluate such independent associations, focusing on potential non-linear patterns, clinical thresholds, and population-specific heterogeneities. Methods: Data from 1951 couples (3788 cycles) were retrospectively analyzed. Multivariable generalized linear models (GLM), generalized estimating equations (GEE), and Cox proportional hazards models assessed first-cycle, per-cycle, and cumulative success, respectively; generalized additive model (GAM) and two-piecewise linear regression characterized non-linear patterns and thresholds. Results: While maternal BMI showed no significant independent association with clinical pregnancy or live birth in the first cycle (all Conclusions: Maternal BMI appears to exhibit a non-linear, context-dependent association with cumulative IUI success, underscoring the potential need for individualized preconception management.
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