Evidence map›Paper›PMID 42318331›Full record

ArticleAdvances in translational research2026

Ovarian-derived signals reprogram hepatic lipid metabolism in aging: Implications for therapeutic targeting of metabolic dysfunction.

Nathan D McCoy, Michael T Kinter, Augusto Schneider, Fabiola Santos, Michal M Masternak, Jeffrey B Mason

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nathan D McCoyCollege of Veterinary Medicine, Department of Veterinary Clinical and Life Sciences, Center for Integrated BioSystems, Utah State University, Logan, UT, 84322, USA.ORCID 0009-0000-5777-7871
Michael T KinterAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.ORCID 0000-0001-7409-8918
Augusto SchneiderFaculdade de Nutrição, Universidade Federal de Pelotas, Pelotas-RS, Brasil.ORCID 0000-0002-3410-2860
Fabiola SantosFaculdade de Nutrição, Universidade Federal de Pelotas, Pelotas-RS, Brasil.ORCID 0000-0003-4145-9304
Michal M MasternakCollege of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA.ORCID 0000-0002-8483-930X
Jeffrey B MasonCollege of Veterinary Medicine, Department of Veterinary Clinical and Life Sciences, Center for Integrated BioSystems, Utah State University, Logan, UT, 84322, USA.ORCID 0000-0003-2459-1186

Funding

NIA NIH HHS R15 AG061795
6 · The paper itself

Abstract

Background and Aim: Aging in mammals is a complex, multifaceted process involving the progressive decline of physiological functions, in which energy metabolism plays a pivotal role. Methods: Liver proteomes were analyzed in CBA/J control mice at 4, 13, 23, and 27 months of age and compared with those of 23-month-old mice that received transplants of young ovarian tissue at 13 months. Results: Ovarian tissue transplantation substantially modulates the expression of Conclusions: Ovarian-derived signals induce metabolic reprogramming in aged mice, characterized by reduced

Indexed as

aginghepatic metabolismlipid metabolismmenopausemetabolic reprogrammingovarian transplantationpharmacological mechanismsPPARα signalingtriglyceridesβ-oxidation

Identifiers

PMID42318331
PMCPMC13274529

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.