ArticleFrontiers in pharmacology2026
UPLC-MS/MS profiling, antioxidant and hemorheological effects of D101 resin-based purified flavonoids from
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Oxidative stress and blood stasis represent critical pathological drivers underlying the progression of cardiovascular and cerebrovascular diseases. Total flavonoids derived from Methods: In this study, orthogonal experiments were performed to optimize the purification conditions of APTF using D101 macroporous resin. Chemic antioxidant activity of purified APTF was evaluated via multiple free radical scavenging assays. A rat model of blood stasis was established to verify the Results: The optimized purification protocol yielded a high APTF recovery rate of 95.112±1.507%. Purified APTF exhibited potent free radical scavenging activity. Discussion: This study established a stable and reliable purification protocol for APTF using D101 macroporous resin. The purified APTF displays prominent antioxidant and blood-activating bioactivities, conferring great application potential for the development of vascular protective functional products and therapeutic agents. Future investigations will focus on screening the active monomer components of APTF and clarifying its underlying molecular mechanisms of action.
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