Evidence map›Paper›PMID 42318359›Full record

ArticleFrontiers in aging2026

The SIRT1-p53 axis drives a ferro-aging-like program and aggravates trophoblast dysfunction in preeclampsia.

Rong Hu, Zhi Chen, Wei Bian, Jing Zhang, Xiaoqin Xu, Hui Xiong, Shaojian Xiang, Yubin Ding, Hongbo Qi, Huan Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rong Hu *Department of Obstetrics, Chongqing University Three Gorges Hospital, Chongqing, China.
Zhi Chen *Department of Gynecology, Chongqing Traditional Chinese Medicine Hospital, Chongqing, China.
Wei Bian *Department of Teaching, Chongqing University Three Gorges Hospital, Chongqing, China.
Jing ZhangDepartment of Obstetrics, Chongqing University Three Gorges Hospital, Chongqing, China.
Xiaoqin XuDepartment of Obstetrics, Chongqing University Three Gorges Hospital, Chongqing, China.
Hui XiongDepartment of Obstetrics, Chongqing University Three Gorges Hospital, Chongqing, China.
Shaojian XiangDepartment of Obstetrics, Chongqing University Three Gorges Hospital, Chongqing, China.
Yubin DingDepartment of Obstetrics and Gynecology, Women and Children's Hospital of Chongqing Medical University, Chongqing, China.
Hongbo QiDepartment of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Huan YangDepartment of Obstetrics, Chongqing University Three Gorges Hospital, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preeclampsia (PE) is a pregnancy-specific syndrome driven by placental dysfunction, and premature placental senescence has increasingly been implicated in its pathogenesis. However, the upstream regulatory mechanisms remain poorly understood. Here, we found that placental SIRT1 expression was reduced in PE and was accompanied by senescence-associated features. In trophoblasts, SIRT1 knockdown enhanced senescence and senescence-associated secretory phenotype (SASP) release, while impairing proliferative capacity, migration, and invasion, whereas pharmacological activation of SIRT1 attenuated placental senescence and ameliorated PE-like manifestations

Indexed as

ferro-aging-likeiron dyshomeostasispreeclampsiapremature placental senescenceSIRT1trophoblast dysfunction

Identifiers

PMID42318359
PMCPMC13272158

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.