Evidence map›Paper›PMID 42318564›Full record

ReviewBioactive materials2026

From blueprint to build: Metal ions in peripheral nerve development and engineering regeneration.

Mouyuan Sun, Yaxian Luo, Zhixu He, Yan Tu, Shuangyang Li, Luying Qin, Jingyu Zhang, Lianjie Peng, Tao Qiu, Tian Zhang and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mouyuan SunStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, China.
Yaxian LuoStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, China.
Zhixu HeStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, China.
Yan TuStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, China.
Shuangyang LiStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, China.
Luying QinStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, China.
Jingyu ZhangStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, China.
Lianjie PengStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, China.
Tao QiuStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, China.
Tian ZhangStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, China.
Huiming WangStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, China.
Haifei ShiDepartment of Hand Surgery, First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310003, China.
Yong HeState Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province, Zhejiang University, Hangzhou, 310027, China.
Mengfei YuStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral nerve injury (PNI) poses a substantial global health burden, affecting over 20 million individuals annually with frequent suboptimal recovery and persistent disability. The inherent limitations of nerve autografts, such as donor site morbidity and limited supply, underscore the clinical importance of nerve guidance conduits (NGCs) as a promising alternative. Nonetheless, the efficacy of current NGCs remains limited by their inability to recapitulate the spatiotemporally precise molecular cues of the native regenerative microenvironment. Our network meta-analysis highlights a significant efficacy gap in current NGCs and underscores the urgent clinical need for novel bioactive strategies. Metal ions have emerged as pivotal therapeutic candidates, capable of orchestrating regeneration by reactivating developmental programs through their tunable release kinetics and pleiotropic effects. By integrating spatiotemporal metal ion dynamics with single-cell transcriptomic data, this review deciphers a conserved, cell-type-specific signaling axis that operates across both development and regeneration. The review further evaluates advanced tissue engineering platforms, ranging from biodegradable metals to functional polymers, coupled with innovative fabrication technologies that enable spatiotemporally controlled ion delivery. This synthesis culminates in a development-inspired engineering blueprint that proposes a paradigm shift from passive structural support to active, development-mimetic instruction, ultimately aiming to accelerate the clinical translation of metal ion-based therapies for PNI (Scheme 1).

Indexed as

Development - inspired tissue engineering scaffoldsMetal ionsPeripheral nerve developmentPeripheral nerve regenerationscRNA-seq

Identifiers

PMID42318564
PMCPMC13273508

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.