Electro-Pyroptosis Immunotherapy of Cancer via Endoplasmic Reticulum-Mitochondria Crosstalk Evoked by Ultrasound-Activated Wireless Electrostimulation.

Guohua Qi, Zutao Chen, Jianmei Li, Ziyi Fu, Zhanfeng Li, Yongdong Jin

Abstract read

In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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5 · Who and what money

Authors and funding

6 authors.

Guohua QiGuangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, China.

Zutao ChenGuangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, China.

Jianmei LiKey Laboratory for Microstructural Material Physics of Hebei Province, School of Science, Yanshan University, Qin huang dao, China.

Ziyi FuKey Laboratory for Microstructural Material Physics of Hebei Province, School of Science, Yanshan University, Qin huang dao, China.

Zhanfeng LiGuangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, China.

Yongdong JinGuangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, China.

Funding

National Natural Science Foundation of China 22474078Scientific Foundation for Youth Scholars of Shenzhen UniversityTechnology development plan project of Guangdong Province 2025A1515012173

6 · The paper itself

Abstract

Effectively inducing endoplasmic reticulum (ER) stress to initiate cell pyroptosis is promising to elevate cancer immunotherapy, as it avoids immune escape of tumor cells and insufficient differentiation of immune cells. However, it remains a major challenge due to the lack of effective ways to induce ER stress. Herein, we reported the conceptually new electro-pyroptosis immunotherapy (EPI-therapy) of cancer via ER-mitochondria crosstalk by wireless electrostimulation (wES), enabled by ultrasound-activatable ER-targeted piezoelectric nanoplatform of FAL&BaTiO

Indexed as

Endoplasmic ReticulumImmunotherapyMitochondriaNeoplasmsPyroptosisUltrasonic WavesWireless TechnologyAnimalsCell Line, TumorElectric StimulationEndoplasmic Reticulum StressHumansMetal NanoparticlesMiceReactive Oxygen SpeciesReactive Oxygen Specieselectro‐pyroptosiselectrostimulationendoplasmic reticulum‐mitochondria crosstalkimmunotherapy

Identifiers

PMID42318666

DOI10.1002/adma.73770

PMCPMC13410642

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.