Evidence map›Paper›PMID 42318824›Full record

Trial reportJournal of obesity2026

A Healthy Diet Intervention Alters Food Preferences and Eating Behaviours Without Changing Appetite, Adipokines or Glucose Homoeostasis.

Litto Tharakan, Troy Merry, Eva Liu, Sara Cooper, Walter Hsu, Chris Hedges, Amber Parry-Strong, Fiona E Lithander, Jeremy Krebs, Andrea Braakhuis

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of obesity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Litto TharakanDepartment of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, auckland.ac.nz.ORCID 0000-0002-8617-0750
Troy MerryDepartment of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, auckland.ac.nz.ORCID 0000-0001-8699-500X
Eva LiuDepartment of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, auckland.ac.nz.
Sara CooperDepartment of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, auckland.ac.nz.
Walter HsuDepartment of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, auckland.ac.nz.
Chris HedgesDepartment of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, auckland.ac.nz.ORCID 0000-0003-1104-0385
Amber Parry-StrongLiggins Institute, University of Auckland, Auckland, New Zealand, auckland.ac.nz.ORCID 0000-0002-5427-9989
Fiona E LithanderLiggins Institute, University of Auckland, Auckland, New Zealand, auckland.ac.nz.ORCID 0000-0003-4542-7924
Jeremy KrebsDepartment of Medicine, University of Otago, Wellington, New Zealand, otago.ac.nz.ORCID 0000-0002-7850-3447
Andrea BraakhuisDepartment of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, auckland.ac.nz.ORCID 0000-0002-6055-0595

Funding

Council of Australasian University LibrariansHigh-Value Nutrition National Science ChallengeUniversity of Auckland
6 · The paper itself

Abstract

purposeThe study aimed to evaluate the influence of a 12-week Mediterranean dietary pattern on eating behaviours, food preferences, appetite, satiety, hunger hormones, adipokines and glucose homoeostasis.

methodsThis study is nested within the He Rourou Whai Painga (HRWP) trial. Adults with a high risk of metabolic disease (waist circumference-based metabolic score, MetSSS score ≥ 0.35) participated in the mixed-meal challenge before and after a 12-week dietary intervention. Questionnaire assessments included the Three Factor Eating Questionnaire (TFEQ) and the Leeds Food Preference Questionnaire (LFPQ). Visual analogue scales (VAS) were used to measure subjective appetite sensations. Blood was drawn in the fasting state and at 15-, 30-, 60-, 90- and 120-min postmeal. The following peptides, hormones and metabolic markers were analysed: adiponectin, ghrelin, leptin, peptide YY (PYY), glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), fibroblast growth factor 21 (FGF21), growth differentiation factor 15 (GDF15), glucose, insulin and C-peptide concentrations.

resultsThere was a significant decrease in uncontrolled eating (UE, p value = 0.0226) and an increase in cognitive restraint (CR, p value = 0.0004) following the intervention diet. Implicit desire for high-fat savoury foods, low-fat savoury foods and fat-appeal bias was significantly reduced after the intervention diet. None of the peptides or metabolic markers changed significantly after the intervention diet. Even though glucose, insulin and C-peptide levels decreased following the diet intervention, none of the values reached statistical significance.

conclusionA healthy diet intervention alters food preferences and eating behaviours without changing appetite, adipokines or glucose homoeostasis.

trial registrationAustralia New Zealand Trial Registry: ACTRN12622000906752.

Indexed as

AdipokinesAppetiteDiet, HealthyDiet, MediterraneanFeeding BehaviorFood PreferencesAdultBlood GlucoseFemaleGhrelinHomeostasisHumansMaleMiddle AgedSurveys and QuestionnairesAdipokinesBlood GlucoseGhrelindietfood rewardimplicit wanting

Identifiers

PMID42318824
PMCPMC13280808

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.