Evidence map›Paper›PMID 42318949›Full record

ArticleInternational journal of molecular medicine2026

Oridonin ameliorates ulcerative colitis by regulating the PI3K/AKT/mTOR signaling pathway to activate autophagy.

Zhongxing Miao, Baohong Liu, Xingzhi Zhou, Mengru Lu, Ni Jia, Huamin Zhang, Ying Qi, Xiaoyu Tan, Qinggao Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhongxing Miao *Immunology Biology Key Laboratory, Yanbian University, Yanji, Jilin 133002, P.R. China.
Baohong Liu *Department of Medical Supervision, Tianjin Binhai New Area Center for Disease Control and Prevention, Tianjin 300451, P.R. China.
Xingzhi Zhou *Health Medicine Translational Research Center, School of Basic Medical Sciences, Dalian University, Dalian, Liaoning 116622, P.R. China.
Mengru LuHealth Medicine Translational Research Center, School of Basic Medical Sciences, Dalian University, Dalian, Liaoning 116622, P.R. China.
Ni JiaHealth Medicine Translational Research Center, School of Basic Medical Sciences, Dalian University, Dalian, Liaoning 116622, P.R. China.
Huamin ZhangDepartment of Central Laboratory, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116001, P.R. China.
Ying QiHealth Medicine Translational Research Center, School of Basic Medical Sciences, Dalian University, Dalian, Liaoning 116622, P.R. China.
Xiaoyu TanDepartment of Clinical Laboratory, Xin Hua Hospital Affiliated to Dalian University, Dalian, Liaoning 116021, P.R. China.
Qinggao ZhangImmunology Biology Key Laboratory, Yanbian University, Yanji, Jilin 133002, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aimed to investigate the therapeutic effects and underlying mechanism of oridonin (ORI) in ulcerative colitis (UC) using the lipopolysaccharide (LPS)‑induced macrophage inflammatory model

Indexed as

AutophagyColitis, UlcerativeDiterpenes, KauranePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionTOR Serine-Threonine KinasesAnimalsCytokinesDextran SulfateDisease Models, AnimalLipopolysaccharidesMaleMiceMice, Inbred C57BLRAW 264.7 CellsCytokinesDextran SulfateDiterpenes, KauraneLipopolysaccharidesmTOR protein, mouseoridoninPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesautophagyinflammationoridoninPI3K/AKT/mTORulcerative colitis

Identifiers

PMID42318949
PMCPMC13299232

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.