ArticleJournal of biological physics2026
A thermodynamically consistent approach to modeling epithelial solute and water transport in the proximal convoluted tubule.
Article in Journal of biological physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
This study presents a novel approach to modeling fluid and ion transport in the proximal convoluted tubule (PCT) of the nephron using bond graphs. Bond graphs provide a robust framework for analyzing complex systems, explicitly depicting multi-domain energy exchange. Leveraging the modular nature of bond graphs, we first defined resistive modules representing membranes and capacitive modules representing solution-filled compartments, then coupled them using circuit theory. Our implementation extends beyond previous bond graph models of physiological processes by explicitly representing volumetric flow as a distinct variable within capacitive modules. In so doing, our model enables the consideration of mechanotransduction effects, where changes in fluid volume can influence membrane transporter activity, a crucial aspect of PCT function. Our bond graph model of the PCT (BG-PCT) comprises four fluid compartments bounded by five distinct membranes. The BG-PCT considers five chemical species (Na
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