miR-125b Attenuates Sepsis-Induced Hippocampal Mitochondrial Fission and Cognitive Impairment via the ROS/p53 Pathway.

Xingshu Ren, Yunan Mo, Lanlan Zhong, Songyun Deng, Yuhang Ai, Lina Zhang

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Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Xingshu Ren *Department of Critical Care Medicine, Hunan Provincial Clinical Research Center for Critical Care Medicine, National Clinical Research Center for Geriatric Diseases, Xiangya Hospital, Central South University, No. 87 Xiang-Ya Road, Changsha, 410008, Hunan Province, China.

Yunan Mo *Department of Critical Care Medicine, Hunan Provincial Clinical Research Center for Critical Care Medicine, National Clinical Research Center for Geriatric Diseases, Xiangya Hospital, Central South University, No. 87 Xiang-Ya Road, Changsha, 410008, Hunan Province, China.

Lanlan ZhongDepartment of Critical Care Medicine, Hunan Provincial Clinical Research Center for Critical Care Medicine, National Clinical Research Center for Geriatric Diseases, Xiangya Hospital, Central South University, No. 87 Xiang-Ya Road, Changsha, 410008, Hunan Province, China.

Songyun DengDepartment of Critical Care Medicine, Hunan Provincial Clinical Research Center for Critical Care Medicine, National Clinical Research Center for Geriatric Diseases, Xiangya Hospital, Central South University, No. 87 Xiang-Ya Road, Changsha, 410008, Hunan Province, China.

Yuhang AiDepartment of Critical Care Medicine, Hunan Provincial Clinical Research Center for Critical Care Medicine, National Clinical Research Center for Geriatric Diseases, Xiangya Hospital, Central South University, No. 87 Xiang-Ya Road, Changsha, 410008, Hunan Province, China.

Lina ZhangDepartment of Critical Care Medicine, Hunan Provincial Clinical Research Center for Critical Care Medicine, National Clinical Research Center for Geriatric Diseases, Xiangya Hospital, Central South University, No. 87 Xiang-Ya Road, Changsha, 410008, Hunan Province, China. zln7095@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis-associated encephalopathy (SAE) is a common complication of sepsis characterized by neuronal injury and cognitive impairment. However, its underlying mechanisms remain unclear. In this study, we investigated the role of miR-125b in sepsis-induced hippocampal injury. A cecal ligation and puncture (CLP) model was established in mice, and miR-125b was overexpressed in the hippocampus using lentiviral vectors. CLP-induced sepsis increased mitochondrial fission and neuronal apoptosis in the hippocampus, accompanied by p53 activation and reduced miR-125b expression. miR-125b overexpression suppressed mitochondrial fission markers, reduced neuronal apoptosis, and improved cognitive deficits. Mechanistically, miR-125b inhibited ROS accumulation and p53 activation, whereas p53 overexpression reversed these protective effects. Conversely, hippocampal knockdown of miR-125b with LV-anti-miR-125b aggravated mitochondrial fission and neuronal apoptosis, further supporting its protective role. These findings indicate that miR-125b protects against sepsis-induced hippocampal injury by regulating the ROS/p53 pathway.

Indexed as

Cognitive DysfunctionHippocampusMicroRNAsMitochondrial DynamicsReactive Oxygen SpeciesSepsisSignal TransductionTumor Suppressor Protein p53AnimalsApoptosisMaleMice, Inbred C57BLNeuronsMicroRNAsMirn125 microRNA, mouseReactive Oxygen SpeciesTumor Suppressor Protein p53Hippocampal neuronal apoptosisMiR-125bMitochondrial fissionROS/p53 signalingSepsis-associated encephalopathy (SAE)

Identifiers

PMID42319582

DOI10.1016/j.biopha.2023.114264

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.