Evidence mapPaperPMID 42320985Full record

ReviewJournal for immunotherapy of cancer2026

Tumor cell ferroptosis in antitumor immunity and immunotherapy efficacy.

Shuyin Li, Thomas Gajewski

Abstract readReview
In one paragraph

Review in Journal for immunotherapy of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shuyin LiDepartment of Pathology, The University of Chicago, Chicago, Illinois, USA.
Thomas GajewskiDepartment of Medicine and the Ben May Department of Cancer Research, The University of Chicago, Chicago, Illinois, USA tgajewsk@bsd.uchicago.edu.

Funding

Overcoming resistance to anti-PD1 immunotherapyR35CA210098 · NCI · UNIVERSITY OF CHICAGO · 2021 to 2025
$3.8M
NCI NIH HHS R35 CA210098
6 · The paper itself

Abstract

Cancer immunotherapy, particularly immune checkpoint blockade (ICB), has represented a major advancement for the treatment of various cancers. Though ICB has been an effective tool in the clinical management of patients, a significant subset of individuals do not respond clinically. This observation has motivated deeper investigations into the mechanisms of efficacy versus resistance to ICB. Of these, tumor cell-intrinsic mechanisms, such as the activation of immune regulatory oncogene pathways or immune selection for antigen-loss variants, have been a promising focus of study. Recent evidence has emerged that ferroptosis, a tumor cell-intrinsic cell death pathway, plays an important role in CD8

Indexed as

FerroptosisImmunotherapyNeoplasmsAnimalsHumansImmunotherapy

Identifiers

PMID42320985
PMCPMC13289365

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.